Valente P, Main E K
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
Obstet Gynecol Clin North Am. 1990 Sep;17(3):607-16.
The role of the placental tissue in the perinatal transmission of HIV is still far from being understood. Significant data regarding transplacental infection have been collected, but differences in technique have led to controversy. It appears clear that many Hofbauer cells are CD4+ and can become infected with HIV. Less certain but probable is infection of trophoblasts themselves. Whether infection is CD4 mediated or via cell-cell fusion is not established. Transplacental traffic of virus and cells remains a little-studied possibility. Further data are needed regarding the fascinating concept of the placenta as a modulator of infection.
胎盘组织在围产期HIV传播中的作用仍远未被了解。关于经胎盘感染已收集了大量数据，但技术差异引发了争议。很明显，许多霍夫鲍尔细胞是CD4+的，并且能够被HIV感染。滋养层细胞本身是否感染尚不确定，但有可能发生感染。感染是由CD4介导还是通过细胞间融合发生尚未明确。病毒和细胞的经胎盘转运仍是一个研究较少的可能性。关于胎盘作为感染调节因子这一引人入胜的概念，还需要更多数据。
