Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Phytother Res. 2013 Jan;27(1):77-85. doi: 10.1002/ptr.4690. Epub 2012 Apr 4.
Aqueous and organic extracts of 27 selected species from five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 196 n-hexane, chloroform, 50% methanol or water extracts of different plant parts were investigated. It was found that extracts of Polygonum hydropiper, Rumex acetosa, Rumex alpinus, Rumex aquaticus, Rumex scutatus and Rumex thyrsiflorus at 10 or 30 µg/mL demonstrated substantial cell growth inhibitory activity (at least 50% inhibition of cell proliferation) against one or more cell lines. R. acetosa and R. thyrsiflorus proved to be the most active and are considered worthy of activity-guided phytochemical investigations.
采用 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐法，对来自于 Carpathian Basin 地区的蓼科（Polygonaceae）五个属（何首乌属、酸模属、贯叶蓼属、何首乌属和酸模属）的 27 种植物的水提物和有机溶剂提取物进行了体外抗增殖活性筛选，供试细胞系包括 HeLa（宫颈上皮腺癌）、A431（皮肤表皮样癌细胞）和 MCF7（乳腺上皮腺癌）。共检测了 196 种不同植物部位的正己烷、氯仿、50%甲醇或水提取物。结果发现，水蓼、酸模、高山酸模、酸模叶蓼、齿果酸模和酸模花的 10 或 30 µg/mL 提取物对一种或多种细胞系表现出显著的细胞生长抑制活性（至少 50%的细胞增殖抑制）。酸模和酸模花被证明是最活跃的，值得进行基于活性的植物化学研究。
