Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Cell Biochem Funct. 2012 Aug;30(6):524-9. doi: 10.1002/cbf.2832. Epub 2012 Apr 4.
A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory-based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in the metabolic and endocrine alterations, including decreased glucose tolerance and insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure. Altogether, evidences point to a possible role of decreased sleep duration in the current epidemic of obesity and therefore present literature highlights the importance of getting enough good sleep for metabolic health. Many aspects still need to be clarified and intervention studies also need to be conducted.
一个减少睡眠时间已成为常见的在过去的一个世纪,和越来越多的证据来自流行病学和基于实验室的研究表明睡眠剥夺是一个新的肥胖的危险因素。在此基础上,本综述检查了睡眠剥夺在代谢和内分泌改变的作用,包括葡萄糖耐量和胰岛素敏感性下降,晚上浓度增加皮质醇,增加水平的ghrelin,降低瘦素水平和增加饥饿和食欲。将讨论如何睡眠限制可能会导致增加食物摄入,导致更大的疲劳,这可能有利于减少能量消耗。总之,有证据表明,睡眠时间减少可能在当前肥胖流行中起作用,因此目前的文献强调了获得足够良好睡眠对代谢健康的重要性。许多方面仍需要澄清,也需要进行干预研究。
