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代谢综合征与心血管自主神经功能障碍之间的联系。

Links between metabolic syndrome and cardiovascular autonomic dysfunction.

作者信息

Garruti G, Giampetruzzi F, Vita M G, Pellegrini F, Lagioia P, Stefanelli G, Bellomo-Damato A, Giorgino F

机构信息

Unit of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantations (D.E.T.O.), University of Bari A. Moro, 70124 Bari, Italy.

出版信息

Exp Diabetes Res. 2012;2012:615835. doi: 10.1155/2012/615835. Epub 2012 Mar 15.

DOI:10.1155/2012/615835
PMID:22474426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3312199/
Abstract

BACKGROUND

Type 2 diabetes (T2D) might occur within metabolic syndrome (MbS). One of the complications of T2D is an impaired (imp) cardiovascular autonomic function (CAF).

AIMS

In subjects with T2D and age ≤ 55 years, the prevalence of impCAF and its relationship with BMI, waist, HbA(1c) values, MbS, hypertension, and family history of T2D and/or hypertension were analysed.

METHODS

180 subjects consecutively undergoing a day hospital for T2D were studied. The IDF criteria were used to diagnose MbS. To detect impCAF, 5 tests for the evaluation of CAF were performed with Cardionomic (Meteda, Italy). Univariate and multivariate analyses were performed.

RESULTS

The prevalence of impCAF and MbS were 33.9% and 67.8%, respectively. Among diabetics with impCAF, 86.9% had MbS. ImpCAF was significantly associated with MbS, overweight, and HbA(1c) > 7%. Both logistic (P = 0.0009) and Poisson (P = 0.0113) models showed a positive association between impCAF and MbS. The degree of ImpCAF showed a positive linear correlation with BMI and HbA(1c) values.

CONCLUSIONS

The study demonstrates that glycaemic control and overweight influence CAF and that T2D + MbS is more strongly associated with impCAF than isolated T2D. We suggest that MbS not only increases the cardiovascular risk of relatively young subjects with T2D but is also associated with impCAF.

摘要

背景

2型糖尿病（T2D）可能发生于代谢综合征（MbS）之中。T2D的并发症之一是心血管自主神经功能（CAF）受损（imp）。

目的

分析年龄≤55岁的T2D患者中impCAF的患病率及其与体重指数（BMI）、腰围、糖化血红蛋白（HbA1c）值、MbS、高血压以及T2D和/或高血压家族史的关系。

方法

对180例因T2D连续入住日间医院的患者进行研究。采用国际糖尿病联盟（IDF）标准诊断MbS。使用意大利Meteda公司的Cardionomic进行5项评估CAF的测试以检测impCAF。进行单因素和多因素分析。

结果

impCAF和MbS的患病率分别为33.9%和67.8%。在患有impCAF的糖尿病患者中，86.9%患有MbS。ImpCAF与MbS、超重以及HbA1c>7%显著相关。逻辑回归模型（P = 0.0009）和泊松模型（P = 0.0113）均显示impCAF与MbS之间存在正相关。ImpCAF的程度与BMI和HbA1c值呈正线性相关。

结论

该研究表明血糖控制和超重会影响CAF，且与单纯T2D相比，T2D + MbS与impCAF的关联更强。我们认为MbS不仅增加了相对年轻的T2D患者的心血管风险，还与impCAF相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/8d9a183dcb72/EDR2012-615835.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/4ac043eef398/EDR2012-615835.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/60992463390d/EDR2012-615835.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/796ef55d2816/EDR2012-615835.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/1f978387db57/EDR2012-615835.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/8d9a183dcb72/EDR2012-615835.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/4ac043eef398/EDR2012-615835.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/60992463390d/EDR2012-615835.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/796ef55d2816/EDR2012-615835.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/1f978387db57/EDR2012-615835.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2388/3312199/8d9a183dcb72/EDR2012-615835.005.jpg

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