Departments of Endocrinology and Metabolism, Huashan Hospital of Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai, 200040, China,
J Endocrinol Invest. 2014 Apr;37(4):385-91. doi: 10.1007/s40618-013-0047-4. Epub 2014 Jan 9.
The cardiovascular autonomic neuropathy (CAN) prevalence is rapidly growing in all populations worldwide. This study aimed to evaluate the reference values for the short-term heart rate variable (HRV) and estimate CAN prevalence in our cross-sectional dataset.
We conducted a large-scale, community-based, cross-sectional study in a Chinese population. Of 2,092 subjects available for data analysis, 371 healthy subjects were selected to reference the values for the short-term HRV. The short-term HRV analysis was performed for all subjects using a computer-aided examination and evaluation system for spectral analysis to investigate changes in autonomic regulation.
In the total sample, the reference value for total power was more than 356.13 ms(2). The cutoff points of 55.45 and 36.64 ms(2) were set for low frequency (LF) and high frequency (HF), respectively. The cutoff points of LFn and HFn were 6.40 and 4.83 ν, respectively. The normative reference of LF/HF ranged from 0.3 to 6.5. Using HRV test (model 1), the estimated age-adjusted CAN prevalence in the total sample was 16.83 %. The estimated age-adjusted CAN prevalence values were 31.07, 21.97 and 20.81 % in DM, HT, and MS patients, respectively.
Our findings provided reference values for short-term HRV. The estimated CAN prevalence was high in the Chinese population.
心血管自主神经病变（CAN）的患病率在全球所有人群中迅速增长。本研究旨在评估短期心率变量（HRV）的参考值，并估计我们的横断面数据集中心血管自主神经病变的患病率。
我们在中国人群中进行了一项大规模的、基于社区的、横断面研究。在可用于数据分析的 2092 名受试者中，选择了 371 名健康受试者作为短期 HRV 的参考值。使用计算机辅助检查和评估系统对所有受试者进行短期 HRV 分析，以研究自主调节的变化。
在总样本中，总功率的参考值大于 356.13ms(2)。低频 (LF) 和高频 (HF) 的截止点分别设定为 55.45 和 36.64ms(2)。LFn 和 HFn 的截止点分别为 6.40 和 4.83 ν。LF/HF 的规范参考范围为 0.3 至 6.5。使用 HRV 测试（模型 1），总样本中估计的年龄调整后的 CAN 患病率为 16.83%。在 DM、HT 和 MS 患者中，估计的年龄调整后的 CAN 患病率分别为 31.07%、21.97%和 20.81%。
我们的研究结果提供了短期 HRV 的参考值。中国人群中估计的 CAN 患病率较高。
