Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, NO, 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040, China.
Eur J Med Res. 2014 Feb 12;19(1):8. doi: 10.1186/2047-783X-19-8.
Cardiovascular autonomic neuropathy (CAN) is rapidly growing in all populations worldwide. Baroreflex sensitivity (BRS) is easily applied as a diagnostic test to a large number of individuals in the general population. However, no study has reported the normal reference values of BRS for the CAN diagnostic test in a Chinese population. The aim of this study was to estimate the normative reference value of BRS, and assess CAN prevalence in our cross-sectional dataset.
We conducted a large-scale, community-based, cross-sectional study in a Chinese population. We performed data analysis on 2,092 subjects. Cardiovascular autonomic function was assessed using spontaneous BRS. A total of 349 healthy subjects were used to perform analysis for the reference value for BRS. The CAN prevalence was calculated in the overall sample, and in patients with diabetes mellitus, patients with hypertension and patients with metabolic syndrome.
In the overall sample, the reference value for total power (TP.brs) was more than 1.96 ms/mmHg. The cut-off points of 1.74 ms/mmHg and 2.53 ms/mmHg were set as high frequency (HF.brs) and low frequency (LF.brs), respectively. CAN diagnostic tests based on the reference value were performed. The estimated CAN prevalence in the overall sample was 20.41% using the BRS test. CAN prevalence was 33.18%, 28.69% and 28.57% in patients with diabetes mellitus, patients with hypertension and patients with metabolic syndrome, respectively.
Our findings provided reference values for BRS. Estimated CAN prevalence was high in this Chinese population, which has become a major public health problem in China.
心血管自主神经病变（CAN）在全球所有人群中迅速增长。压力反射敏感性（BRS）作为一种诊断测试，可以很容易地应用于大量普通人群中的个体。然而，尚无研究报告 BRS 在中国人群中用于 CAN 诊断测试的正常参考值。本研究旨在估计 BRS 的正常参考值，并评估我们的横断面数据集中 CAN 的患病率。
我们在中国人群中进行了一项大规模的、基于社区的横断面研究。我们对 2092 名受试者进行了数据分析。使用自发 BRS 评估心血管自主神经功能。共有 349 名健康受试者用于分析 BRS 的参考值。在总样本中计算了总的 CAN 患病率，并在糖尿病患者、高血压患者和代谢综合征患者中计算了 CAN 患病率。
在总样本中，总功率（TP.brs）的参考值大于 1.96 ms/mmHg。将 1.74 ms/mmHg 和 2.53 ms/mmHg 分别设定为高频（HF.brs）和低频（LF.brs）的截断点。根据参考值进行了 BRS 诊断测试。使用 BRS 测试估计的总样本中的 CAN 患病率为 20.41%。在糖尿病患者、高血压患者和代谢综合征患者中，CAN 的患病率分别为 33.18%、28.69%和 28.57%。
我们的研究结果为 BRS 提供了参考值。在中国人群中，估计的 CAN 患病率较高，这已成为中国的一个主要公共卫生问题。
