Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA.
Gastroenterol Res Pract. 2012;2012:642923. doi: 10.1155/2012/642923. Epub 2012 Feb 15.
Disorders of the hepatobiliary system are relatively common extraintestinal manifestations of inflammatory bowel disease (IBD). These disorders are sometimes due to a shared pathogenesis with IBD as seen in primary sclerosing cholangitis (PSC) and small-duct primary sclerosing cholangitis (small-duct PSC). There are also hepatobiliary manifestations such as cholelithiasis and portal vein thrombosis that occur due to the effects of chronic inflammation and the severity of bowel disease. Lastly, medications used in IBD such as sulfasalazine, thiopurines, and methotrexate can adversely affect the liver. It is important to be cognizant of these disorders as some do have serious long-term consequences. The management of these disorders often requires the expertise of multidisciplinary teams to achieve the best outcomes.
肝胆系统疾病是炎症性肠病（IBD）较常见的肠道外表现。这些疾病的发病机制与 IBD 部分相同，如原发性硬化性胆管炎（PSC）和小胆管型PSC。此外，还存在因慢性炎症和肠道疾病严重程度导致的肝胆系统表现，如胆石症和门静脉血栓形成。最后，IBD 治疗中使用的药物（如柳氮磺胺吡啶、硫嘌呤和甲氨蝶呤）也可能对肝脏产生不良影响。了解这些疾病非常重要，因为其中一些疾病会产生严重的长期后果。这些疾病的治疗通常需要多学科团队的专业知识，以实现最佳治疗效果。
