Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Front Immunol. 2022 Jul 8;13:883682. doi: 10.3389/fimmu.2022.883682. eCollection 2022.
Mesalamine (MES), also known as 5-aminosalicylic acid, is effective in treating mild to moderate ulcerative colitis (UC). The mechanisms of its actions are not fully elucidated. The aim of this study was to investigate the effects of MES treatment on intestinal microbiota and immune system in an dextran sulfate sodium (DSS)-induced UC model in postweaning piglets. Eighteen weaned piglets were assigned randomly to the following treatments: control group (CON, distilled water), DSS group (DSS, 3% DSS), and MES group (MES, 3% DSS + 2 g/day MES). Our results showed that MES treatment alleviates DSS-induced colitis in piglets, as evidenced by a reduced diarrhea index score and increased average daily gain ( < 0.05). This is accompanied by decreased diamine oxidase activity, D-lactate level ( < 0.05), and attenuated mucosal damage. MES treatment also decreased the abundance of and reduced colon CD11b macrophage and CD3 T-cell infiltrations in piglets with DSS-induced colitis ( < 0.05). Collectively, these data indicate that MES treatment-mediated colitis protection may involve microbiota and immune cell alterations.
美沙拉嗪（MES），又称 5-氨基水杨酸，对治疗轻度至中度溃疡性结肠炎（UC）有效。其作用机制尚未完全阐明。本研究旨在研究美沙拉嗪治疗对断奶仔猪葡聚糖硫酸钠（DSS）诱导 UC 模型肠道微生物群和免疫系统的影响。18 头断奶仔猪被随机分为以下处理组：对照组（CON，蒸馏水）、DSS 组（DSS，3%DSS）和 MES 组（MES，3%DSS+2g/天 MES）。我们的结果表明，MES 治疗减轻了仔猪的 DSS 诱导的结肠炎，表现在腹泻指数评分降低和平均日增重增加（<0.05）。这伴随着二胺氧化酶活性、D-乳酸水平的降低（<0.05）和粘膜损伤的减轻。MES 治疗还降低了和减少了 DSS 诱导的结肠炎仔猪结肠 CD11b 巨噬细胞和 CD3 T 细胞浸润（<0.05）。总之，这些数据表明，MES 治疗介导的结肠炎保护可能涉及微生物群和免疫细胞的改变。
