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静脉注射胺碘酮后发生尖端扭转型室速和持续性QTc间期延长

Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone.

作者信息

Kotsia Anna P, Dimitriadis Georgios, Baltogiannis Giannis G, Kolettis Theofilos M

机构信息

Department of Cardiology, University Hospital of Ioannina, 1 Stavrou Niarxou Avenue, 45110 Ioannina, Greece.

出版信息

Case Rep Med. 2012;2012:673019. doi: 10.1155/2012/673019. Epub 2012 Mar 5.

DOI:10.1155/2012/673019
PMID:22474460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3303706/
Abstract

We report a case of torsade de pointes after intravenous amiodarone and concurrent hypokalemia. Despite treatment cessation and correction of electrolyte abnormalities, excessive QTc prolongation was noted, which persisted for 14 days. This prolonged course for QTc normalization may be attributed to the high rate of amiodarone loading and concurrent electrolyte disturbances coupled with possible underlying individual variability in pharmacokinetics.

摘要

我们报告一例静脉注射胺碘酮后并发低钾血症导致尖端扭转型室速的病例。尽管停止治疗并纠正了电解质异常，但仍观察到QTc过度延长，这种情况持续了14天。QTc恢复正常的过程延长可能归因于胺碘酮负荷率高、并发电解质紊乱以及药代动力学方面可能存在的个体差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/0566c9bc871d/CRIM2012-673019.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/9bb9cfc99030/CRIM2012-673019.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/60e862fdf685/CRIM2012-673019.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/fac3a5e388c0/CRIM2012-673019.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/0566c9bc871d/CRIM2012-673019.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/9bb9cfc99030/CRIM2012-673019.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/60e862fdf685/CRIM2012-673019.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/fac3a5e388c0/CRIM2012-673019.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1c4/3303706/0566c9bc871d/CRIM2012-673019.004.jpg

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Amiodarone-associated macroscopic T-wave alternans and torsade de pointes unmasking the inherited long QT syndrome.胺碘酮相关的宏观T波交替和尖端扭转型室速揭示遗传性长QT综合征
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