College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.
Evid Based Complement Alternat Med. 2012;2012:741824. doi: 10.1155/2012/741824. Epub 2012 Mar 1.
Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation and endothelial dysfunction. In the present study, we investigated the protective effect of the aqueous extract of Portulaca oleracea L. (AP), an edible plant used as a folk medicine, on diabetic vascular complications. The db/db mice were treated with AP (300 mg/kg/day, p.o.) for 10 weeks, and AP treatment markedly lowered blood glucose, plasma triglyceride, plasma level of LDL-cholesterol, and systolic blood pressure in diabetic db/db mice. Furthermore, AP significantly increased plasma level of HDL-cholesterol and insulin level. The impairment of ACh- and SNP-induced vascular relaxation of aortic rings were ameliorated by AP treatment in diabetic db/db mice. This study also showed that overexpression of VCAM-1, ICAM-1, E-selectin, MMP-2, and ET-1 were observed in aortic tissues of untreated db/db mice, which were significantly suppressed by treatment with AP. We also found that the insulin immunoreactivity of the pancreatic islets remarkably increased in AP treated db/db mice compared with untreated db/db mice. Taken together, AP suppresses hyperglycemia and diabetic vascular inflammation, and prevents the development of diabetic endothelial dysfunction for the development of diabetes and its vascular complications.
2 型糖尿病与微血管和大血管并发症的发生呈显著加速相关，如糖尿病血管炎症和内皮功能障碍。在本研究中，我们研究了马齿苋（Portulaca oleracea L.）水提物（AP）对糖尿病血管并发症的保护作用。AP（300mg/kg/天，口服）治疗 db/db 小鼠 10 周，可显著降低糖尿病 db/db 小鼠的血糖、血浆甘油三酯、LDL-胆固醇水平和收缩压。此外，AP 还显著增加了 HDL-胆固醇和胰岛素水平。AP 治疗改善了糖尿病 db/db 小鼠 ACh 和 SNP 诱导的主动脉环血管舒张功能障碍。本研究还表明，未经治疗的 db/db 小鼠主动脉组织中 VCAM-1、ICAM-1、E-选择素、MMP-2 和 ET-1 的表达明显上调，而 AP 治疗可显著抑制其表达。我们还发现，与未经治疗的 db/db 小鼠相比，AP 处理的 db/db 小鼠胰岛的胰岛素免疫反应明显增加。综上所述，AP 可抑制高血糖和糖尿病血管炎症，预防糖尿病内皮功能障碍的发生，从而预防糖尿病及其血管并发症的发生。
