Unité Interactions Hôte-Agents pathogènes, Institut de Recherche Biomédicale des Armées, Centre de Recherche du Service de Santé des Armées, BP 87, 24 avenue des Maquis du Grésivaudan 38702 La Tronche Cedex, France.
Toxins (Basel). 2012 Feb;4(2):83-97. doi: 10.3390/toxins4020083. Epub 2012 Feb 6.
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.
炭疽杆菌是炭疽的病原体，通过其营养体产生的外毒素获得了毒力，由形成致死毒素 (LT) 和水肿毒素 (ET) 的三个成分组成。到目前为止，人们对这些毒素对真核细胞骨架的影响知之甚少。在这里，我们提供了一个关于毒素对细胞骨架结构的一般影响的概述。因此，我们将讨论炭疽毒素如何与其受体相互作用，并可能破坏细胞外基质与细胞骨架之间的界面。然后，我们分析了已经描述的毒素对细胞骨架的分子作用，接着讨论了细胞骨架如何帮助病原体破坏吞噬作用或血管完整性等一般细胞过程。
