Karp Robert J, Winkfield-Royster Tawana, Weedon Jeremy
Children's Hospital at Downstate, State University of New York (SUNY), Downstate Medical Center, P. O. Box 49, Brooklyn, NY 11203, USA.
J Nutr Metab. 2012;2012:158643. doi: 10.1155/2012/158643. Epub 2012 Feb 22.
Background. While rapid early weight gain are common in children who become obese later in life, so is growth faltering in the first 3 months of life. Objective. We seek to determine what relationship weight gain in the first six months of age, separated into two 3-month periods, have with the BMI of children ages 4 to 6 years in an inner-city community. Subjects. A convenience sample cohort of 154 children attending an inner-city clinic. Methods. Consecutive charts were reviewed retrospectively. Age, gender, birth weight and weight change in the first and second 3 months of life were introduced as fixed factors using mixed linear models with BMI in years 4 to 6 as the dependent variable. Results. Weight change quartile in the first 3 months of life did not predict of BMI in years 4 to 6; however, weight changes quartiles during months 4 to 6 were significant predictors for subsequent overweight. Conclusion. The data presented herein suggest that, for this specific population, weight gain can be promoted when it is most essential. It is necessary, however, to identify intermediary variables that could affect outcomes in this and other communities.
背景。虽然早期体重快速增加在后来肥胖的儿童中很常见，但在生命的前3个月生长发育迟缓的情况也很常见。目的。我们试图确定在一个市中心社区中，分为两个3个月时间段的6个月龄内体重增加与4至6岁儿童的体重指数（BMI）之间存在何种关系。对象。一个来自市中心诊所的154名儿童的便利样本队列。方法。对连续的病历进行回顾性审查。将年龄、性别、出生体重以及生命前3个月和后3个月的体重变化作为固定因素引入，使用混合线性模型，以4至6岁时的BMI作为因变量。结果。生命前3个月的体重变化四分位数不能预测4至6岁时的BMI；然而，第4至6个月期间的体重变化四分位数是随后超重的显著预测因素。结论。本文所呈现的数据表明，对于这一特定人群，在最关键的时候可以促进体重增加。然而，有必要确定可能影响这个及其他社区结果的中间变量。
