Eckhardt Cara L, Eng Heather, Dills John L, Wisner Katherine L
a School of Community Health, Portland State University , Portland , OR 97201 , USA .
b Department of Epidemiology , Graduate School of Public Health, University of Pittsburgh , Pittsburgh , PA 15261 , USA , and.
Ann Hum Biol. 2016;43(1):85-90. doi: 10.3109/03014460.2014.1002533. Epub 2015 Jun 12.
Infant rapid weight gain (RWG) may predict subsequent obesity, but there are inconsistencies in the growth references and age intervals used for assessment.
This study evaluated whether the prevalence of RWG (an increase of >0.67 in weight-for-age z-score) differed by growth reference (2006 WHO standards vs 2000 CDC references) and age interval of assessment (0-3, 0-6, 6-12 and 0-12 months). Pooled data from singleton term infants from two observational studies on maternal mood disorders during pregnancy were used (n = 161). Differences in RWG prevalence by growth reference and age interval were tested using Cochran's Q and McNemar's tests.
The CDC reference produced a higher RWG prevalence (14% of infants additionally categorized as RWG, p < 0.0001) within the 0-3 month age interval compared to the WHO standards; this pattern was reversed for the 6-12 and 0-12 month intervals. RWG prevalence did not differ across age interval within the WHO standards, but did differ with the CDC references (range: 22% for 0-3 months to 4.2% for 6-12 months, p < 0.0001).
Caution is advised when comparing studies with different criteria for RWG. Future studies should use the 2006 WHO standards and a consistent age interval of evaluation.
婴儿快速体重增加（RWG）可能预示着随后的肥胖，但用于评估的生长参考标准和年龄区间存在不一致。
本研究评估了按生长参考标准（2006年世界卫生组织标准与2000年美国疾病控制与预防中心参考标准）和评估年龄区间（0至3个月、0至6个月、6至12个月以及0至12个月）划分的RWG（年龄别体重Z评分增加>0.67）患病率是否存在差异。使用了来自两项关于孕期母亲情绪障碍的观察性研究的单胎足月儿汇总数据（n = 161）。采用 Cochr an's Q检验和McNemar检验来检测按生长参考标准和年龄区间划分的RWG患病率差异。
与世界卫生组织标准相比，美国疾病控制与预防中心参考标准在0至3个月年龄区间内产生了更高的RWG患病率（另外14%的婴儿被归类为RWG，p < 0.0001）；在6至12个月以及0至12个月区间，这种模式则相反。在世界卫生组织标准内，RWG患病率在各年龄区间无差异，但在美国疾病控制与预防中心参考标准下存在差异（范围：0至3个月为22%，6至12个月为4.2%，p < 0.0001）。
在比较采用不同RWG标准的研究时应谨慎。未来的研究应使用2006年世界卫生组织标准和一致的评估年龄区间。
