婆罗洲五种火炬姜属植物的精油成分、细胞毒性及抗菌活性
Essential oil composition, cytotoxic and antibacterial activities of five Etlingera species from Borneo.
作者信息
Vairappan Charles Santhanaraju, Nagappan Thilahgavani, Palaniveloo Kishneth
机构信息
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.
出版信息
Nat Prod Commun. 2012 Feb;7(2):239-42.
Essential oils obtained by hydrodistillation from the rhizomes of Etlingera pyramidosphaera (K. Schum.) R. M. Sm, E. megalocheilos (Griff.) A.D. Poulsen, comb. nov., E. coccinea (Blume) S. Sakai & Nagam, E. elatior (Jack) R. M. Sm, and E. brevilabrum (Valeton) R. M. Sm were analyzed by GCMS. The highest oil yield was obtained from E. pyramidosphaera (0.45%), followed by E. elatior (0.38%), E. coccinea (0.30%), E. brevilabrum (0.28%) and E. megalocheilos (0.25%). The major constituents of the essential oils were oxygenated monoterpenes, followed by sesquiterpenes, oxygenated sesquiterpenes, oxygenated diterpenes and diterpenes. The essential oils from E. pyramidosphaera and E. brevilabrum exhibited the best cytotoxicity against MCF 7 (LC50: 7.5 +/- 0.5 mg mL(-1)) and HL 60 (LC50: 5.0 mg mL(-1)), respectively. Strong inhibition was also observed for the essential oils of E. coccinea and E. megalocheilos against Staphylococcus aureus (MIC: 8.0 +/- 0.5 mg mL(-1), and 5.0 +/- 0.5 mg mL(-1)) and Streptococcus pyrogenes (MIC: 6.0 +/- 0.5 mg mL(-1) and 8.0 +/- 0.5 mg mL(-1)).
采用气相色谱 - 质谱联用（GCMS）分析法对从金字塔球姜（Etlingera pyramidosphaera (K. Schum.) R. M. Sm）、巨唇姜（E. megalocheilos (Griff.) A.D. Poulsen, comb. nov.）、红姜花（E. coccinea (Blume) S. Sakai & Nagam）、火炬姜（E. elatior (Jack) R. M. Sm）和短唇姜（E. brevilabrum (Valeton) R. M. Sm）的根茎中通过水蒸馏法获得的挥发油进行了分析。挥发油得率最高的是金字塔球姜（0.45%），其次是火炬姜（0.38%）、红姜花（0.30%）、短唇姜（0.28%）和巨唇姜（0.25%）。挥发油的主要成分是氧化单萜类化合物，其次是倍半萜类化合物、氧化倍半萜类化合物、氧化二萜类化合物和二萜类化合物。金字塔球姜和短唇姜的挥发油分别对MCF - 7细胞（半数致死浓度：7.5 ± 0.5 mg mL⁻¹）和HL - 60细胞（半数致死浓度：5.0 mg mL⁻¹）表现出最佳的细胞毒性。红姜花和巨唇姜的挥发油对金黄色葡萄球菌（最低抑菌浓度：8.0 ± 0.5 mg mL⁻¹和5.0 ± 0.5 mg mL⁻¹）和化脓性链球菌（最低抑菌浓度：6.0 ± 0.5 mg mL⁻¹和8.0 ± 0.5 mg mL⁻¹）也表现出较强的抑制作用。
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