Department of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Göttingen, Germany.
Restor Neurol Neurosci. 2012;30(3):255-63. doi: 10.3233/RNN-2012-110208.
Transcranial direct current stimulation (tDCS) was reintroduced about a decade ago as a tool for inducing long-lasting changes in cortical excitability. Recently it has been shown that both motor and cognitive functions can be influenced by tDCS. Here, we tested the effect of tDCS on the blood-oxygen level dependent (BOLD) signal evoked by coherent visual motion using functional magnetic resonance imaging (fMRI).
The subjects underwent 10 min of cathodal and sham tDCS, applied over the right MT+. Following stimulation, random dot kinomatograms (RDK) with different percentages (10%, 30%, 50%) of coherently moving dots were presented.
All motion stimuli activated MT+ in both stimulation conditions. However, cathodal stimulation led to an increase in fMRI signal in MT+ when compared to sham stimulation. This effect did not depend on the coherence level of the visual stimulus.
Here, we show for the first time, that cathodal tDCS stimulation leads to elevated fMRI signal in the human visual cortex.
经颅直流电刺激（tDCS）在大约十年前被重新引入，作为诱导皮质兴奋性长期变化的一种工具。最近的研究表明，tDCS 可以影响运动和认知功能。在这里，我们使用功能磁共振成像（fMRI）测试了 tDCS 对相干视觉运动诱发的血氧水平依赖（BOLD）信号的影响。
受试者接受了 10 分钟的阴极和假 tDCS 治疗，施加在右侧 MT+上。刺激后，呈现不同百分比（10%、30%、50%）的相干运动点的随机点运动图（RDK）。
所有运动刺激在两种刺激条件下都激活了 MT+。然而，与假刺激相比，阴极刺激导致 MT+中的 fMRI 信号增加。这种效应不依赖于视觉刺激的相干水平。
在这里，我们首次表明，阴极 tDCS 刺激导致人类视觉皮层的 fMRI 信号升高。
