Eberl S, Eriksson T, Svedberg O, Norling J, Henderson D, Lam P, Fulham M
Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Appl Radiat Isot. 2012 Jun;70(6):922-30. doi: 10.1016/j.apradiso.2012.03.007. Epub 2012 Mar 18.
Upgrades and optimisation achieved 160 μA total target current operation of a GE PETtrace cyclotron in dual target mode for the routine production of [(18)F]FDG for >2 years. Approximately 900 GBq of (18)F(-) and >500 GBq of [(18)F]FDG can be produced routinely in a single production run, meeting the routine [(18)F]FDG requirements with our customer base and achieving economies of scale. Production of >1 TBq of (18)F(-) in a single run was achieved. Reliability, saturation and synthesis yields were not adversely affected.
升级和优化使通用电气PETtrace回旋加速器在双靶模式下实现了160 μA的总目标电流运行，用于常规生产[(18)F]FDG超过2年。在单次生产运行中，通常可生产约900 GBq的(18)F(-)和超过500 GBq的[(18)F]FDG，满足了我们客户群对常规[(18)F]FDG的需求并实现了规模经济。单次运行实现了超过1 TBq的(18)F(-)的生产。可靠性、饱和度和合成产率均未受到不利影响。
