年轻大脑与脑震荡：影像学作为诊断和预后的生物标志物。
The young brain and concussion: imaging as a biomarker for diagnosis and prognosis.
机构信息
Center for Pain and the Brain, Children's Hospital Boston, Harvard Medical School, United States.
出版信息
Neurosci Biobehav Rev. 2012 Jul;36(6):1510-31. doi: 10.1016/j.neubiorev.2012.03.007. Epub 2012 Mar 28.
Abstract
Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.
摘要
脑震荡（轻度创伤性脑损伤（mTBI））是一个严重的儿科公共卫生问题。尽管人们的认识有所提高，但对脑震荡对中枢神经系统结构和功能的急性和慢性影响仍缺乏全面的了解。在这里，我们回顾了在儿童和青少年时期，发育中的大脑中脑震荡的定义、流行病学和后遗症，目前的数据来自对病理生理学和神经影像学的研究。这些发现可能有助于更好地理解创伤性脑损伤的神经后果，进而可能导致开发脑生物标志物来改善对患有脑震荡的儿科患者的识别、管理和预后。
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