Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
Immunol Res. 2012 Dec;54(1-3):4-13. doi: 10.1007/s12026-012-8307-5.
Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T-cell-independent pathway for B-cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly "frontline" B cells located in the marginal zone of the spleen and in the intestine.
成熟 B 细胞通过免疫球蛋白 (Ig) 类别转换和体细胞高频突变产生保护性免疫，这两个 Ig 基因多样化过程通常需要与表达 CD40 配体的 T 细胞发生同源相互作用。这种 T 细胞依赖性途径提供了免疫记忆，但发生速度相对较慢。因此，它必须与通过先天免疫细胞释放的 CD40 配体样分子的更快、T 细胞非依赖性途径整合，以激活 B 细胞，这些分子对微生物产物做出反应。在这里，我们讨论了我们对先天免疫系统和 B 细胞之间相互作用的理解的最新进展，特别是位于脾脏边缘区和肠道中的“前沿”B 细胞。
