Department of Food Science and Human Nutrition, Colorado State University, 1571 Campus Mail, 206 Gifford Building, Fort Collins, CO 80523, USA.
Plant Foods Hum Nutr. 2012 Jun;67(2):111-9. doi: 10.1007/s11130-012-0279-z.
Obesity is closely associated with increased incidence of cardiovascular diseases, cancer, insulin resistance, and immune dysfunction, and thus obesity-mitigation strategies should take into account these secondary pathologies in addition to promoting weight loss. Recent studies indicate that black cumin (Nigella sativa) has cardio-protective, anti-cancer, anti-diabetic, antioxidant, and immune-modulatory properties. While black cumin and/or its major bioactive constituent, thymoquinone have demonstrated bioactivity in a variety of disease models, the mechanisms of action are largely unknown. Given the growing interest in and the use of functional foods and nutraceuticals, as well as the increase in obesity and chronic diseases worldwide, further research into the therapeutic/preventive effects of black cumin may be beneficial.
肥胖与心血管疾病、癌症、胰岛素抵抗和免疫功能障碍的发病率增加密切相关，因此，肥胖缓解策略除了促进体重减轻外，还应考虑这些继发性病理。最近的研究表明，黑孜然（Nigella sativa）具有心脏保护、抗癌、抗糖尿病、抗氧化和免疫调节特性。虽然黑孜然及其主要生物活性成分，百里醌在各种疾病模型中表现出生物活性，但作用机制在很大程度上尚不清楚。鉴于对功能性食品和营养保健品的兴趣日益增加，以及全球肥胖和慢性疾病的增加，进一步研究黑孜然的治疗/预防作用可能是有益的。
