González Ana M, Maceira Benito M, Pérez Estefanía, Cabrera Vicente M, López Alfonso J, Larruga José M
Department of Genetics, Faculty of Biology, University of La Laguna, La Laguna, Tenerife, Spain.
Genet Test Mol Biomarkers. 2012 Aug;16(8):859-64. doi: 10.1089/gtmb.2011.0207. Epub 2012 Apr 5.
Type 1 and type 2 diabetes, complicated with renal disease, have a significantly higher incidence in the Canary Islands than in mainland Spain and other European countries. Present-day Canarian inhabitants consist of a mixed population with North African indigenous and European colonizer ancestors who have rapidly evolved from a rural to an urban life style. The aim of this work was to assess the possible role of genetic and environmental factors on diabetes-related end-stage renal disease incidence in the Canary Islands.
For both types of diabetes there is an ethnic susceptibility increased by diabetes family history. Whereas the Y-chromosome does not play a significant role, mitochondrial DNA (mtDNA) haplogroup differences point to a maternal origin for this ethnic predisposition, confirming susceptible and protective effects for haplogroups J and T, respectively. In addition, urban life style seems to be an additional risk factor for type 1 diabetes.
The maternal ethnic predisposition to diabetes complicated with kidney disease detected in the Canary Islands signals mtDNA and X-chromosome markers as the best candidates to uncover the genetic predisposition to this disease.
1型和2型糖尿病合并肾病在加那利群岛的发病率显著高于西班牙大陆及其他欧洲国家。当今的加那利群岛居民是一个混合群体，其祖先包括北非原住民和欧洲殖民者，他们已迅速从乡村生活方式转变为城市生活方式。这项研究的目的是评估遗传和环境因素对加那利群岛糖尿病相关终末期肾病发病率的可能作用。
对于这两种类型的糖尿病，糖尿病家族史都会增加种族易感性。Y染色体不起重要作用，而线粒体DNA（mtDNA）单倍群差异表明这种种族易感性源于母系，分别证实了单倍群J和T的易感和保护作用。此外，城市生活方式似乎是1型糖尿病的另一个危险因素。
在加那利群岛发现的糖尿病合并肾病的母系种族易感性表明，mtDNA和X染色体标记是揭示该疾病遗传易感性的最佳候选因素。
