吗氯贝胺（Ro 11 - 1163）与丙咪嗪治疗抑郁症的对比研究
Moclobemide (Ro 11-1163) versus imipramine in the treatment of depression.
作者信息
Casacchia M, Moll E
机构信息
Clinica Psichiatrica, Università-L'Aquila, Rome, Italy.
出版信息
Acta Psychiatr Scand Suppl. 1990;360:43. doi: 10.1111/j.1600-0447.1990.tb05324.x.
Moclobemide and imipramine were compared single-blind in 2 groups of 20 depressed patients (75% and 65% endogenous depression respectively). There was no significant difference between the 2 groups in improvement on the Hamilton Rating Scale for Depression. The final overall assessment of efficacy was good or very good in 80% of the moclobemide patients and 55% on imipramine. Tolerance was good to very good in 95% of moclobemide patients, compared with 80% on imipramine. No severe adverse effects were reported in either group.
对两组各20名抑郁症患者进行了单盲试验，比较吗氯贝胺和丙咪嗪的疗效（两组内源性抑郁症患者分别占75%和65%）。在汉密尔顿抑郁评定量表的改善情况方面，两组之间无显著差异。吗氯贝胺组80%的患者最终总体疗效评估为良好或非常好，丙咪嗪组为55%。吗氯贝胺组95%的患者耐受性良好至非常好，丙咪嗪组为80%。两组均未报告严重不良反应。
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