Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D-60596 Frankfurt, Germany.
Toxicon. 2012 Jul;60(1):66-9. doi: 10.1016/j.toxicon.2012.03.017. Epub 2012 Mar 28.
Tetrodotoxin (TTX) and its analogue 6-epiTTX had been detected in the red-spotted newt, Notophthalmus viridescens. Thirty specimens of a population from Pennsylvania, USA were histologically examined for the presence of intestinal parasites. More than 50% were found to be infected with nematodes (Trichocephalidae), trematodes or cestodes (Pseudophyllidae). The mean values of TTX and 6-epiTTX in parasitized and in non-parasitized newts were not significantly different. Using a monoclonal antibody-based immunoenzymatic technique, TTX was localized in the intestinal tissue as well as in the parasites indicating that they accumulate the toxin and suggesting that TTX and 6-epiTTX are not providing protection from parasites to the newts.
在红斑钝口螈中检测到了河豚毒素 (TTX) 和其类似物 6-表 TTX。对来自美国宾夕法尼亚州的一个种群的 30 个标本进行了组织学检查，以检测是否存在肠道寄生虫。超过 50%的标本被发现感染了线虫（Trichocephalidae）、吸虫或绦虫（Pseudophyllidae）。寄生和非寄生红斑钝口螈的 TTX 和 6-表 TTX 的平均值没有显著差异。使用基于单克隆抗体的免疫酶技术，TTX 被定位在肠道组织以及寄生虫中，表明它们积累了毒素，并表明 TTX 和 6-表 TTX 并没有为钝口螈提供抵御寄生虫的保护。
