You Jie, Yue YaJun, Xing Feng, Xia Wei, Lai ShaoYang, Zhang FengLei
Luohu Center for Disease Control and Prevention, Department of Public Health, Shenzhen, China.
Luohu Center for Disease Control and Prevention, Department of Chemical Laboratory, Shenzhen, China.
Clinics (Sao Paulo). 2015 Jan;70(1):24-9. doi: 10.6061/clinics/2015(01)05.
To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness.
A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry.
The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera.
This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future.
为调查中国东南部雷州一起不寻常的河豚毒素中毒事件，开展病例系列分析以确定病因。
共有22人出现中毒症状，包括舌头麻木、头晕、恶心以及肢体麻木和无力。从患者食用的一批虾虎鱼中形态学鉴定出两种有毒物种，即犬牙细棘鰕虎鱼和云斑裸颊虾虎鱼。采用液相色谱-串联质谱法检测血液和虾虎鱼样本中的河豚毒素水平。
剩余熟制虾虎鱼中的河豚毒素水平测定为2090.12μg/kg。犬牙细棘鰕虎鱼的毒性水平为：肌肉中1858.29μg/kg，内脏中1997.19μg/kg；云斑裸颊虾虎鱼的毒性水平为：肌肉中2783.00μg/kg，内脏中2966.21μg/kg。
此次疫情表明对虾虎鱼中毒风险的评估不足。此外，未来应明确有毒物种、气候和海洋藻类之间的关系。
