Mass Spectrometry Research Centre (MSRC) and PROTEOBIO Research Groups, Department of Chemistry, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland.
Department of Chemistry, University of Pune, Pune 411007, India.
Toxins (Basel). 2014 Feb 21;6(2):693-755. doi: 10.3390/toxins6020693.
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.
河豚毒素（TTX）是一种天然存在的毒素，已导致人类中毒和死亡。其通常的毒性途径是通过摄入受污染的河豚鱼，河豚鱼是一种美食，尤其是在日本。人们曾认为 TTX 只存在于东南亚地区，但最近的研究表明，这种毒素已经扩散到太平洋和地中海地区。目前还没有针对 TTX 的已知解毒剂，因为它是一种强大的钠离子通道抑制剂。本综述旨在收集迄今为止有关 TTX 及其类似物的相关信息，特别强调其结构、病因、分布、作用以及用于检测的分析方法。
