气管黏膜相关淋巴组织淋巴瘤：病例报告
Mucosa-associated lymphoid tissue lymphoma of the trachea: case report.
作者信息
Magliari Maria Elisa Ruffolo, Aquino Renata Telles Rudge de, Gonçalves Anna Luiza Lobão, Marioni Fábio, Bernardi Fabíola del Carlo, Brasil Sérgio, Almeida Joaquim Antonio da Fonseca, Andrade Benedito Juarez, Chiattone Carlos Sérgio, Lima Carlos Alberto da Conceição
机构信息
Discipline of Internal Medicine, Department of Clinical Medicine, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brazil.
出版信息
Sao Paulo Med J. 2012;130(2):126-9. doi: 10.1590/s1516-31802012000200010.
CONTEXT
Mucosa-associated lymphoid tissue (MALT) lymphomas are most commonly found in the stomach, lungs, orbital soft tissue, salivary glands and thyroid. Involvement of the trachea is extremely rare.
CASE REPORT
This report describes a rare case of MALT lymphoma of the trachea in a 71-year-old woman who presented with a one-year history of coughing, dyspnea, hoarseness and weight loss. There was an infiltrative lesion in the mid-trachea. The anatomopathological diagnosis was only made from the fifth endoscopic biopsy attempt. Immunochemotherapy consisting of rituximab, cyclophosphamide, vincristine and prednisone (R-COP) induced complete remission of the symptoms and endoscopic lesion.
CONCLUSIONS
MALT lymphoma of the trachea is extremely rare and indolent disease. It has to be considered in the differential diagnosis of airway lesions. It is crucial to obtain an anatomopathological diagnosis from a specialized pathologist. Immunochemotherapy with R-COP induced complete remission of the disease.
背景
黏膜相关淋巴组织（MALT）淋巴瘤最常见于胃、肺、眼眶软组织、唾液腺和甲状腺。气管受累极为罕见。
病例报告
本报告描述了一例71岁女性气管MALT淋巴瘤的罕见病例，该患者有一年的咳嗽、呼吸困难、声音嘶哑和体重减轻病史。气管中部有一个浸润性病变。仅在第五次内镜活检尝试时才做出解剖病理学诊断。由利妥昔单抗、环磷酰胺、长春新碱和泼尼松（R-COP）组成的免疫化疗使症状和内镜下病变完全缓解。
结论
气管MALT淋巴瘤极为罕见且为惰性疾病。在气道病变的鉴别诊断中必须考虑到该病。由专业病理学家做出解剖病理学诊断至关重要。R-COP免疫化疗使疾病完全缓解。
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