Cañas Carlos A, Cañas Felipe
Rheumatology Unit, Fundación Valle del Lili, ICESI University, Avenida Simón Bolívar Cra. 98 No.18-49, Cali, Colombia.
Autoimmune Dis. 2012;2012:784315. doi: 10.1155/2012/784315. Epub 2012 Mar 14.
It is an inherent part of living to be in constant modification, which are due to answers resulting from environmental changes. The different systems make adaptations based on natural selection. With respect to the immune system of mammals, these changes have a lot to do with the interactions that occur continuously with other living species, especially microorganisms. The immune system is primarily designed to defend from germs and this response triggers inflammatory reactions which must be regulated in order not to generate damage to healthy tissue. The regulatory processes were added over time to prevent such damage. Through evolution the species have stored "an immunological experience," which provides information that is important for developing effective responses in the future. The human species, which is at a high level of evolutionary immunological accumulation, have multiple immune defense strategies which, in turn, are highly regulated. Imbalances in these can result in autoimmunity."There is nothing permanent except change."(Heraclitus).
处于不断变化之中是生命的一个固有部分，这些变化是对环境变化所做出的反应所致。不同的系统基于自然选择进行适应。就哺乳动物的免疫系统而言，这些变化与它同其他生物物种，尤其是微生物持续发生的相互作用密切相关。免疫系统主要旨在抵御病菌，这种反应会引发炎症反应，而炎症反应必须得到调节，以免对健康组织造成损害。随着时间的推移，调节过程不断增加以防止此类损害。通过进化，物种积累了“免疫经验”，这些经验为未来产生有效的反应提供重要信息。处于进化免疫积累高水平的人类物种拥有多种免疫防御策略，而这些策略反过来又受到高度调节。这些策略的失衡会导致自身免疫。“除了变化，没有什么是永恒的。”（赫拉克利特）
