从老鼠到人，再到免疫：进化系统生物学的一个案例。
Of mice, men and immunity: a case for evolutionary systems biology.
机构信息
Center for Veterinary Sciences and Comparative Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
出版信息
Nat Immunol. 2018 May;19(5):421-425. doi: 10.1038/s41590-018-0084-4.
Abstract
Animal models have been tremendously useful to translational research, but there is a need to maximize their predictive value to human disease. This Comment proposes novel strategies that consider evolutionary history and the presence, absence or modification of molecular networks in one species that are being studied in the other.
摘要
动物模型在转化研究中非常有用，但需要最大限度地提高其对人类疾病的预测价值。本文提出了一些新的策略，这些策略考虑了一个物种的进化历史以及另一个物种中正在研究的分子网络的存在、缺失或修饰。
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