Ishimaru Daichi, Ohno Takatoshi, Maeda Masato, Nishimoto Yutaka, Shimizu Katsuji
Department of Orthopaedic Surgery, Takayama Red cross Hospital, Tenman-cho 3-11, Takayama, Gifu 506-8550, Japan.
Chemother Res Pract. 2010;2010:240763. doi: 10.1155/2010/240763. Epub 2010 Jun 27.
Treatment with a combination of chemotherapy and radiotherapy is known to be associated with oesophageal stricture in both children and adults with malignancies. However, oesophageal stricture resulting from chemotherapy alone is a rare complication, with few reports on it. We experienced a rare paediatric case of oesophageal stricture caused by chemotherapy for osteosarcoma of the left distal femur. After completion of the chemotherapy course, the patient showed dysphagia caused by the oesophageal stricture and underwent balloon dilatation for the oesophageal stricture. After balloon dilatation, he was able to ingest solid foods, and the oesophagus was normal without any strictures at the last follow-up (20 months after ballooning). Therefore, oesophageal stricture should be considered as a complication of treatment with chemotherapy alone in children with malignancies.
已知化疗和放疗联合治疗会使患有恶性肿瘤的儿童和成人出现食管狭窄。然而,单纯化疗导致的食管狭窄是一种罕见的并发症,相关报道较少。我们遇到了一例罕见的儿科病例,该患儿因左股骨远端骨肉瘤接受化疗后出现食管狭窄。化疗疗程结束后,患者因食管狭窄出现吞咽困难,并接受了食管狭窄球囊扩张术。球囊扩张术后,他能够摄入固体食物,在最后一次随访(球囊扩张术后20个月)时食管正常,无任何狭窄。因此,对于患有恶性肿瘤的儿童,食管狭窄应被视为单纯化疗治疗的一种并发症。