高敏C反应蛋白：与心血管危险因素的关联以及在女性青少年和年轻成年人中的追踪情况
High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.
作者信息
Morrison John A, Glueck Charles J, Daniels Stephen R, Wang Ping, Stroop Davis M, Horn Paul S
机构信息
Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
出版信息
ISRN Pediatr. 2011;2011:707206. doi: 10.5402/2011/707206. Epub 2011 Jan 24.
Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24-26 (partial R(2) = 12.3% P < .0001, 6.6% P = .0012). Changes in BMI and triglyceride (partial R(2) = 8.5% P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.
目的。我们评估了青少年的人体测量指标、血脂、胰岛素、血糖和血压，以确定与高敏C反应蛋白（hsCRP）相关的因素及其在年轻成年人中的追踪情况。方法。对589名女学生进行了为期十年的前瞻性研究，其中321名黑人，268名白人。结果。hsCRP在种族或口服避孕药使用方面无差异（P>.08）。hsCRP在16至25岁（r = 0.77）、16至26岁（r = 0.50）、24至26岁（r = 0.66）和25至26岁（r = 0.71）之间具有追踪性，所有P≤.02。通过逐步回归分析，在16岁时，腰围占hsCRP变异的44.8%；在24、25和26岁时，BMI分别占33.1%、34.4%和31.1%，所有P<.0001。胆固醇和BMI的变化与24至26岁时hsCRP的变化相关（偏R(2)=12.3%，P<.0001；6.6%，P=.0012）。BMI和甘油三酯的变化与25至26岁时hsCRP的变化相关（偏R(2)=8.5%，P=.0001；3.3%，P=.0045）。结论。hsCRP在16至26岁之间具有追踪性，BMI、腰围和胆固醇是主要决定因素。
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