Morrison John A, Glueck Charles J, Daniels Stephen R, Wang Ping, Stroop Davis M, Horn Paul S
Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
ISRN Pediatr. 2011;2011:707206. doi: 10.5402/2011/707206. Epub 2011 Jan 24.
Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24-26 (partial R(2) = 12.3% P < .0001, 6.6% P = .0012). Changes in BMI and triglyceride (partial R(2) = 8.5% P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.
目的。我们评估了青少年的人体测量指标、血脂、胰岛素、血糖和血压，以确定与高敏C反应蛋白（hsCRP）相关的因素及其在年轻成年人中的追踪情况。方法。对589名女学生进行了为期十年的前瞻性研究，其中321名黑人，268名白人。结果。hsCRP在种族或口服避孕药使用方面无差异（P>.08）。hsCRP在16至25岁（r = 0.77）、16至26岁（r = 0.50）、24至26岁（r = 0.66）和25至26岁（r = 0.71）之间具有追踪性，所有P≤.02。通过逐步回归分析，在16岁时，腰围占hsCRP变异的44.8%；在24、25和26岁时，BMI分别占33.1%、34.4%和31.1%，所有P<.0001。胆固醇和BMI的变化与24至26岁时hsCRP的变化相关（偏R(2)=12.3%，P<.0001；6.6%，P=.0012）。BMI和甘油三酯的变化与25至26岁时hsCRP的变化相关（偏R(2)=8.5%，P=.0001；3.3%，P=.0045）。结论。hsCRP在16至26岁之间具有追踪性，BMI、腰围和胆固醇是主要决定因素。
