Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Ocul Surf. 2012 Apr;10(2):108-16. doi: 10.1016/j.jtos.2012.02.001. Epub 2012 Feb 8.
In September 2010, a Symposium in Florence, Italy, was held to address the unmet need for global treatments for dry eye disease (DED). It was sponsored by The Tear Film & Ocular Surface Society (TFOS; www.TearFilm.org) and co-sponsored by the Association for Research in Vision & Ophthalmology (www.arvo.org). The Symposium objectives were two-fold: first, to discuss accepted and emerging clinical endpoints of DED with regulatory experts from around the world; and second, to consider how to improve clinical trials of treatments for DED. The Symposium focused on the personal and collective burden of DED, as well as the developmental and regulatory challenges associated with generating new DED therapeutics. This article provides a synopsis of many of the presentations, discussions and recommendations of this Symposium.
2010 年 9 月，意大利佛罗伦萨举行了一次研讨会，旨在解决干眼症（DED）全球治疗方法的未满足需求。该研讨会由泪膜和眼表面协会（TFOS；www.TearFilm.org）主办，并得到了视觉与眼科研究协会（www.arvo.org）的共同赞助。研讨会的目标有两个：首先，与来自世界各地的监管专家讨论 DED 的公认和新兴临床终点；其次，考虑如何改善 DED 治疗的临床试验。该研讨会重点关注 DED 的个人和集体负担，以及与开发新的 DED 疗法相关的发展和监管挑战。本文概述了该研讨会的许多演讲、讨论和建议。
