School of Optometry, University of California Berkeley, Berkeley, CA, 94720, USA; Vision Science Program, University of California Berkeley, Berkeley, CA, 94720, USA.
Department of Medicine and Anesthesia, University of California, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Ocul Surf. 2021 Jan;19:104-114. doi: 10.1016/j.jtos.2020.04.008. Epub 2020 Apr 29.
In the last twenty years an impressive body of evidence in diverse inflammatory animal disease models and human tissues, has established polyunsaturated fatty acids (PUFA) derived specialized-pro-resolving mediators (SPM), as essential mediators for controlling acute inflammation, immune responses, wound healing and for resolving acute inflammation in many non-ocular tissues. SPM pathways and receptors are highly expressed in the ocular surface where they regulate wound healing, nerve regeneration, innate immunity and sex-specific regulation of auto-immune responses. Recent evidence indicates that in the eye these resident SPM networks are important for maintaining ocular surface health and immune homeostasis. Here, we will review and discuss evidence for SPMs and other PUFA-derived mediators as important endogenous regulators, biomarkers for ocular surface health and disease and their therapeutic potential.
在过去的二十年中，在各种炎症性动物疾病模型和人体组织中，令人印象深刻的证据表明，多不饱和脂肪酸（PUFA）衍生的特异性促解决介质（SPM）是控制急性炎症、免疫反应、伤口愈合和解决许多非眼部组织急性炎症的必需介质。SPM 途径和受体在眼部表面高度表达，在眼部表面调节伤口愈合、神经再生、先天免疫和自身免疫反应的性别特异性调节。最近的证据表明，在眼睛中，这些常驻 SPM 网络对于维持眼部表面健康和免疫稳态非常重要。在这里，我们将回顾和讨论 SPM 以及其他 PUFA 衍生介质作为重要的内源性调节剂、眼部表面健康和疾病的生物标志物及其治疗潜力的证据。
