Secchi A G, Tognon M S, Leonardi A
Institute of Ophthalmology, University of Padova School of Medicine, Italy.
Am J Ophthalmol. 1990 Dec 15;110(6):641-5. doi: 10.1016/s0002-9394(14)77061-8.
We treated 11 patients with vernal keratoconjunctivitis for four to nine months with topical cyclosporine as a 2% dilution in castor oil. No significant side effects occurred, except for mild and transient burning upon administration. Within the first 15 days, both symptoms and signs of the condition improved significantly, and these results were maintained throughout the entire treatment. Relapses of the disease occurred two to four months after the end of the therapy. A double-masked clinical trial of nine patients (2% cyclosporine in castor oil vs castor oil alone) confirmed the results. Treated eyes improved significantly for both signs and symptoms as compared to control eyes. Topical cyclosporine may, therefore, be considered an effective substitute for corticosteroids, with an excellent anti-inflammatory activity in patients with both corticosteroid-dependent and corticosteroid-resistant vernal keratoconjunctivitis.
我们用蓖麻油稀释成2%的环孢素局部治疗11例春季角结膜炎患者，治疗时间为4至9个月。除给药时出现轻微短暂的烧灼感外，未发生明显副作用。在治疗的前15天内，病情的症状和体征均显著改善，且这些结果在整个治疗过程中得以维持。治疗结束后2至4个月疾病复发。一项针对9例患者的双盲临床试验（2%环孢素蓖麻油制剂与单纯蓖麻油对照）证实了上述结果。与对照眼相比，治疗眼的症状和体征均显著改善。因此，局部用环孢素可被视为皮质类固醇的有效替代药物，对皮质类固醇依赖型和皮质类固醇抵抗型春季角结膜炎患者均具有出色的抗炎活性。
