Kumar Piyush, Lal Niharika Ranjan, Mondal Ashim Kumar, Mondal Avijit, Gharami Ramesh C, Maiti Arunasis
Medical College & Hospital, Kolkata, India.
Dermatol Online J. 2012 Mar 15;18(3):1.
Zinc is an essential trace element that is an integral component of many metallo-enzymes in the body and thus serves many biological functions. The clinical presentation of zinc deficiency varies and depends on serum zinc level. Whereas a significantly low serum zinc level results in clinical features similar to acrodermatitis enteropathica, mild hypozincemia presents with a less characteristic appearance; hence it may be underdiagnosed. Recognition of various cutaneous lesions is required for suspecting and identifying cases of zinc deficiency. Although many laboratory tests are useful, therapeutic response in suspected cases remains the gold standard of diagnosis. Serum zinc estimation alone is not very reliable because disease activity may not necessarily correlate with serum zinc level. Zinc supplementation results in a rapid response and the skin lesions heal without permanent sequelae. However, pigmentary alterations may persist longer. Predisposing factors should be identified and corrected. This brief review summarizes the identification and management of clinical zinc deficiency.
锌是一种必需的微量元素，是人体许多金属酶的组成成分，因而具有多种生物学功能。锌缺乏的临床表现各异，取决于血清锌水平。血清锌水平显著降低会导致类似肠病性肢端皮炎的临床特征，而轻度低锌血症的表现则不那么典型；因此，它可能未被充分诊断。怀疑和识别锌缺乏病例需要认识各种皮肤病变。虽然许多实验室检查很有用，但疑似病例的治疗反应仍然是诊断的金标准。仅血清锌测定不太可靠，因为疾病活动不一定与血清锌水平相关。补充锌会带来快速反应，皮肤病变愈合后不留永久性后遗症。然而，色素改变可能会持续更长时间。应识别并纠正诱发因素。这篇简要综述总结了临床锌缺乏的识别与管理。
