Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul 34134, Turkey; Division of Cell & Molecular Biology, Faculty of Natural Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul 34134, Turkey.
Cancer Lett. 2012 Oct 1;323(1):58-61. doi: 10.1016/j.canlet.2012.03.036. Epub 2012 Apr 3.
Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggested that functional VGSC expression enhances various in vitro cell behaviours, such as directional motility, that would be involved in the metastatic cascade. However, it is not known if VGSC activity promotes metastasis in vivo. Here, using the Copenhagen rat model of prostate cancer and blocking VGSC activity in primary tumours with tetrodotoxin, we show (1) that the number of lung metastasis is reduced by >40% and (2) that lifespan is significantly improved.
已有研究报道，在许多癌细胞系和组织中电压门控钠离子通道（VGSCs）出现表观遗传上调。此外，大量实验证据表明，功能性 VGSC 表达增强了各种体外细胞行为，如定向迁移，这可能涉及转移级联。然而，VGSC 活性是否促进体内转移尚不清楚。在这里，我们使用前列腺癌的哥本哈根大鼠模型，并使用河豚毒素阻断原发性肿瘤中的 VGSC 活性，结果表明：（1）肺转移的数量减少了>40%；（2）生存期显著提高。
