Delaune Déborah, Janvier Frédéric, Rapp Christophe, Gérôme Patrick, Méchaï Frédéric, Fabre Michel, Soler Charles, Mérens Audrey
Hôpital d'instruction des armées Bégin, Saint-Mandé, École du Val de Grâce, Paris, France.
Ann Biol Clin (Paris). 2012 Mar-Apr;70(2):231-6. doi: 10.1684/abc.2012.0664.
Mycobacterium bovis (M. bovis) is a cause of zoonosis. It is rare in developed countries since cattle control. We report four cases of M. bovis infection in people aged more 60 years. They were probably infected during infancy, consuming unpasteurized milk. It is the main transmission mode in developing countries where veterinary controls aren't made. M. bovis infections clinical aspects are varied and treatment is complicated by natural pyrazinamide resistance. Recent diagnostic methods using molecular biology are quick and specific and facilitate identification.
牛分枝杆菌是一种人畜共患病的病原体。自实施牛群管控以来，在发达国家已较为罕见。我们报告了4例60岁以上人群感染牛分枝杆菌的病例。他们可能在婴儿期因饮用未经巴氏消毒的牛奶而感染。这是在未实施兽医管控的发展中国家的主要传播方式。牛分枝杆菌感染的临床症状多样，且由于对吡嗪酰胺天然耐药，治疗较为复杂。近期使用分子生物学的诊断方法快速且特异，有助于进行鉴定。
