Suzuki Kosuke, Kaneda Yoshihisa, Izumo Takayuki, Nakao Yoshihiro, Iidaka Toshiko, Horii Chiaki, Muraki Shigeyuki, Oka Hiroyuki, Kawaguchi Hiroshi, Akune Toru, Hashizume Hiroshi, Yamada Hiroshi, Nakamura Kozo, Tanaka Sakae, Yoshimura Noriko
Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo 113-8655, Japan.
Institute for Science of Life, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Nutrients. 2025 Jan 30;17(3):517. doi: 10.3390/nu17030517.
As a result of aging societies, the increasing number of older adults requiring nursing care has become a serious issue and the extension of healthy life expectancy has become an urgent priority. Ergothioneine (EGT) is a sulfur-containing amino acid found in foods such as mushrooms. Low EGT blood concentrations have been reported to be associated with the risk of onset and progression of various diseases. However, the distribution of EGT blood concentrations and their association with dietary habits in the Japanese general population remains unclear. This cross-sectional study was conducted using data from the third survey of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study, which analyzed 1457 participants (474 men and 983 women) aged ≥ 40 years. Serum EGT concentrations and their association with dietary habits were analyzed. Serum EGT concentrations (1) peaked in the 70s in men and the 60s in women, (2) were higher in women than in men, and (3) showed a significant positive correlation with fish intake and nutrients commonly found in fish. In the present study, we report for the first time an age- and sex-specific serum EGT distribution in a Japanese population and its association with dietary habits, particularly fish intake. These findings help define normal and abnormal EGT levels and suggest new potential sources of EGT.
由于社会老龄化，需要护理的老年人数量不断增加已成为一个严重问题，延长健康预期寿命已成为当务之急。麦角硫因（EGT）是一种含硫氨基酸，存在于蘑菇等食物中。据报道，血液中EGT浓度低与各种疾病的发病和进展风险有关。然而，日本普通人群中EGT血液浓度的分布及其与饮食习惯的关系仍不清楚。 这项横断面研究使用了骨关节炎/骨质疏松症抗残疾研究（ROAD）第三次调查的数据，该研究分析了1457名年龄≥40岁的参与者（474名男性和983名女性）。分析了血清EGT浓度及其与饮食习惯的关系。血清EGT浓度（1）在男性70多岁和女性60多岁时达到峰值，（2）女性高于男性，（3）与鱼类摄入量和鱼类中常见的营养成分呈显著正相关。 在本研究中，我们首次报告了日本人群中按年龄和性别划分的血清EGT分布及其与饮食习惯，特别是鱼类摄入量的关系。这些发现有助于定义正常和异常的EGT水平，并提示EGT的新潜在来源。
