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约氏乳杆菌La1（LC1）对蒙古沙鼠胃中幽门螺杆菌总体定植水平的降低作用及其对幽门螺杆菌运动性和黏附性的体外活性。

Reduction of overall Helicobacter pylori colonization levels in the stomach of Mongolian gerbil by Lactobacillus johnsonii La1 (LC1) and its in vitro activities against H. pylori motility and adherence.

作者信息

Isobe Hirokazu, Nishiyama Akihito, Takano Tomomi, Higuchi Wataru, Nakagawa Saori, Taneike Ikue, Fukushima Yoichi, Yamamoto Tatsuo

机构信息

Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

出版信息

Biosci Biotechnol Biochem. 2012;76(4):850-2. doi: 10.1271/bbb.110921. Epub 2012 Apr 7.

DOI:10.1271/bbb.110921
PMID:22484956
Abstract

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.

摘要

研究了约氏乳杆菌La1（LC1）对胃中幽门螺杆菌定植的影响。接种LC1的蒙古沙鼠中幽门螺杆菌的定植和胃炎程度明显低于对照动物。LC1培养上清液（>10 kDa部分）抑制幽门螺杆菌的运动，并在人胃上皮细胞中诱导细菌聚集，提示LC1产品具有临床应用潜力。

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