链脲佐菌素诱导糖尿病大鼠中肌醇和肌醇脂质代谢的酶
Enzymes of myo-inositol and inositol lipid metabolism in rats with streptozotocin-induced diabetes.
作者信息
Whiting P H, Palmano K P, Hawthorne J N
出版信息
Biochem J. 1979 Jun 1;179(3):549-53. doi: 10.1042/bj1790549.
Abstract
Diabetes, with only mild ketosis, was induced in male rats by a single injection of streptozotocin. After 12 weeks the specific activities of enzymes concerned with the metabolism of inositol and of inositol lipids were measured in various tissues. Inositol 1-phosphate synthase (EC 5.5.1.4) was most active in testis and the activity was significantly less in diabetic rats than in controls on a similar diet. Inositol oxygenase (EC 1.13.99.1), which converts myo-inositol into glucuronic acid, was also less active in kidney from diabetic animals. CDP-diacylglycerol-inositol phosphatidyltransferase (EC 2.7.8.11) and phosphatidylinositol 4-phosphate kinase (EC 2.7.1.68) showed decreased specific activities in brain and sciatic nerve of diabetic rats. By contrast the diabetic state did not affect the specific activities of phosphatidylinositol kinase (EC 2.7.1.67) or phosphatidylinositol 4,5-bisphosphate phosphatase (EC 3.1.3.36) in these tissues. The results are discussed in relation to diabetic neuropathy.
摘要
通过单次注射链脲佐菌素在雄性大鼠中诱导出仅伴有轻度酮症的糖尿病。12周后，测定了各种组织中与肌醇和肌醇脂质代谢相关的酶的比活性。肌醇1-磷酸合酶（EC 5.5.1.4）在睾丸中活性最高，在食用类似饮食的糖尿病大鼠中，其活性明显低于对照组。将肌醇转化为葡萄糖醛酸的肌醇加氧酶（EC 1.13.99.1）在糖尿病动物的肾脏中活性也较低。CDP-二酰甘油-肌醇磷脂酰转移酶（EC 2.7.8.11）和磷脂酰肌醇4-磷酸激酶（EC 2.7.1.68）在糖尿病大鼠的脑和坐骨神经中显示出比活性降低。相比之下，糖尿病状态并未影响这些组织中磷脂酰肌醇激酶（EC 2.7.1.67）或磷脂酰肌醇4,5-二磷酸磷酸酶（EC 3.1.3.36）的比活性。结合糖尿病神经病变对结果进行了讨论。
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