Ertas Ibrahim Egemen, Sayhan Sevil, Karagoz Gurhan, Yildirim Yusuf
Department of Gynecologic Oncology, Aegean Obstetrics and Gynecology Education and Research Hospital, Izmir, Turkey.
J Obstet Gynaecol Res. 2012 Jun;38(6):948-52. doi: 10.1111/j.1447-0756.2011.01807.x. Epub 2012 Apr 9.
Primary signet-ring cell carcinoma (SRCC) of the breast is an uncommon variant, accounting for 2-4.5% of all primary breast cancers. Secondary SRCC of the endometrium is very rare and usually originates from the breast or gastrointestinal tract. A 54-year-old, postmenopausal woman with a past history of breast cancer four years previously was admitted with abnormal uterine bleeding. An endometrial biopsy revealed undifferentiated adenocarcinoma with signet-ring cells. The patient underwent laparotomy and cytoreductive surgery was performed. Pathological analysis and immunohistochemical tests demonstrated a uterine (endomyometrial) metastasis of breast SRCC. Omentum, peritoneal surfaces and retroperitoneal lymph nodes also included tumoral tissue with signet-ring cell morphology. The patient received adjuvant systemic chemotherapy with adriamycin, cyclophosphamide and paclitaxel. This case report discusses the patient's clinical characteristics and the role of cytoreductive surgery on patient survival in SRCC of the breast metastasizing to the uterus.
原发性乳腺印戒细胞癌（SRCC）是一种罕见的变异类型，占所有原发性乳腺癌的2 - 4.5%。子宫内膜继发性SRCC非常罕见，通常起源于乳腺或胃肠道。一名54岁绝经后女性，4年前有乳腺癌病史，因子宫异常出血入院。子宫内膜活检显示为伴有印戒细胞的未分化腺癌。患者接受了剖腹手术并进行了肿瘤细胞减灭术。病理分析和免疫组化检测显示为乳腺SRCC的子宫（子宫内膜肌层）转移。大网膜、腹膜表面和腹膜后淋巴结也包含具有印戒细胞形态的肿瘤组织。患者接受了阿霉素、环磷酰胺和紫杉醇辅助全身化疗。本病例报告讨论了该患者的临床特征以及肿瘤细胞减灭术在乳腺SRCC转移至子宫患者生存中的作用。
