School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Colloids Surf B Biointerfaces. 2012 Jun 15;95:254-7. doi: 10.1016/j.colsurfb.2012.03.008. Epub 2012 Mar 27.
Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44 nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2 mV) and hydrodynamic size (∼1 μm) and there was no significant difference in their uptake amount 18 h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4 kW, 250 kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.
分别合成了直径约为 13nm 和 44nm 的超顺磁和铁磁磁铁矿纳米粒子，并评估了它们的摄取量和加热效率，以将其应用于磁热疗。这两种纳米粒子具有几乎相同的zeta 电位（+10.2 mV）和水动力粒径（约 1μm），并且在添加到培养基 18 小时后，它们的摄取量没有明显差异。内化后，当施加足够高的外部磁场（4kW，250kHz）以通过磁滞损耗产生热量时，铁磁纳米粒子在人乳腺癌细胞（MCF-7）中显示出比超顺磁纳米粒子更高的加热效率，随后具有高铁磁纳米粒子含量的 MCF-7 细胞死亡。
