Chin Siau Wui, Azman Adzzie-Shazleen, Tan Ji Wei
School of Science Monash University Malaysia Subang Jaya Malaysia.
Health Sci Rep. 2024 Jul 16;7(7):e2251. doi: 10.1002/hsr2.2251. eCollection 2024 Jul.
The difficulty in treating chronic wounds due to the prolonged inflammation stage has affected a staggering 6.5 million people, accompanied by 25 billion USD annually in the United States alone. A 1.9% rise in chronic wound prevalence among Medicare beneficiaries was reported from 2014 to 2019. Besides, the global wound care market values were anticipated to increase from USD 20.18 billion in 2022 to USD 30.52 billion in 2030, suggesting an expected rise in chronic wounds financial burdens. The lack of feasibility in using traditional dry wound dressings sparks hydrogel development as an alternative approach to tackling chronic wounds. Since ancient times, honey has been used to treat wounds, including burns, and ongoing studies have also demonstrated its wound-healing capabilities on cellular and animal models. However, the fluidity and low mechanical strength in honey hydrogel necessitate the incorporation of other polymers. Therefore, this review aims to unravel the characteristics and feasibility of natural (chitosan and gelatin) and synthetic (polyvinyl alcohol and polyethylene glycol) polymers to be incorporated in the honey hydrogel.
Relevant articles were identified from databases (PubMed, Google Scholar, and Science Direct) using keywords related to honey, hydrogel, and polymers. Relevant data from selected studies were synthesized narratively and reported following a structured narrative format.
The importance of honey's roles and mechanisms of action in wound dressings were discussed. Notable studies concerning honey hydrogels with diverse polymers were also included in this article to provide a better perspective on fabricating customized hydrogel wound dressings for various types of wounds in the future.
Honey's incapability to stand alone in hydrogel requires the incorporation of natural and synthetic polymers into the hydrogel. With this review, it is hoped that the fabrication and commercialization of the desired honey composite hydrogel for wound treatment could be brought forth.
由于炎症阶段延长，慢性伤口治疗困难，这影响了多达650万人，仅在美国每年就造成250亿美元的损失。据报道，2014年至2019年医疗保险受益人中慢性伤口患病率上升了1.9%。此外，全球伤口护理市场价值预计将从2022年的201.8亿美元增至2030年的305.2亿美元，这表明慢性伤口的经济负担预计会增加。传统干性伤口敷料缺乏可行性，促使水凝胶作为一种治疗慢性伤口的替代方法得以发展。自古以来，蜂蜜就被用于治疗伤口，包括烧伤，目前的研究也已在细胞和动物模型上证明了其伤口愈合能力。然而，蜂蜜水凝胶的流动性和低机械强度需要加入其他聚合物。因此，本综述旨在阐明天然（壳聚糖和明胶）和合成（聚乙烯醇和聚乙二醇）聚合物加入蜂蜜水凝胶的特性和可行性。
使用与蜂蜜、水凝胶和聚合物相关的关键词，从数据库（PubMed、谷歌学术和科学Direct）中识别相关文章。对所选研究的相关数据进行叙述性综合，并按照结构化叙述格式进行报告。
讨论了蜂蜜在伤口敷料中的作用和作用机制的重要性。本文还纳入了关于含不同聚合物的蜂蜜水凝胶的显著研究，以便更好地展望未来为各类伤口制造定制水凝胶伤口敷料的前景。
蜂蜜在水凝胶中无法单独使用，需要将天然和合成聚合物加入水凝胶中。通过本综述，希望能够推动用于伤口治疗的理想蜂蜜复合水凝胶的制造和商业化。
