Department of Public Health Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Regul Toxicol Pharmacol. 2012 Jun;63(1):166-70. doi: 10.1016/j.yrtph.2012.03.012. Epub 2012 Apr 2.
Smokers who have their first cigarette shortly after waking, an indicator of nicotine dependence, have substantially higher cotinine levels. There is controversy regarding the role of menthol in nicotine dependence. We hypothesized that menthol smokers have a shorter time to first cigarette (TTFC), and tested whether any statistical association actually reflects increased dependence by measuring nicotine uptake (e.g. cotinine) in the same group of smokers. A cross-sectional community-based study was conducted that included 495 black and white daily cigarette smokers. Results showed a trend between menthol smoking and a shorter TTFC (P < 0.04 in blacks). Menthol was not an independent predictor of cotinine or an effect modifier with TTFC on cotinine levels in blacks and whites. These results show that while menthol in tobacco is associated with an indicator of nicotine dependence in blacks, menthol was not associated with biological uptake of nicotine in black and white smokers.
刚醒来就吸第一支烟的吸烟者，这是尼古丁依赖的一个指标，其可的宁水平明显更高。薄荷醇在尼古丁依赖中的作用存在争议。我们假设薄荷醇吸烟者的第一支烟时间（TTFC）更短，并通过在同一组吸烟者中测量尼古丁摄取（如可的宁）来测试任何统计关联是否实际上反映了依赖性的增加。进行了一项基于社区的横断面研究，其中包括 495 名黑人和白人日常吸烟者。结果显示，薄荷醇吸烟与 TTFC 更短之间存在趋势（黑人中 P < 0.04）。在黑人和白人中，薄荷醇不是可的宁或 TTFC 对可的宁水平的效应修饰剂的独立预测因子。这些结果表明，虽然烟草中的薄荷醇与黑人中尼古丁依赖的一个指标有关，但薄荷醇与黑人和白人吸烟者中尼古丁的生物摄取无关。
