Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
Retina. 2012 Oct;32(9):1892-9. doi: 10.1097/IAE.0b013e3182497141.
To quantitatively analyze cystoid macular edema (CME) using scanning laser ophthalmoscope in the modified dark-field imaging.
We studied 37 eyes with CME associated with different diseases before and after treatment. The CME area was measured with the modified dark-field imaging and fluorescein angiography. The best-corrected visual acuity, mean deviation and macular sensitivity measured by Humphrey automated perimetry, and foveal thickness and macular volume determined by optical coherence tomography were investigated.
The CME area could be clearly outlined in 50% with the fluorescein angiography and in 100% with the modified dark-field imaging (P < 0.0001). The CME area calculated using the modified dark-field imaging was significantly correlated with that using the fluorescein angiography (P = 0.0001). Before treatment, the CME area calculated using the modified dark-field imaging was significantly correlated with only the macular volume (P = 0.0230). Three months after treatment, decrease in the CME area was significantly correlated with improvement in the best-corrected visual acuity, mean deviation, macular sensitivity, foveal thickness, and macular volume (P < 0.05 for all).
Our findings indicate that scanning laser ophthalmoscope in the modified dark-field imaging can measure the CME area and is useful in analyzing CME quantitatively. The findings can also be used to evaluate the effectiveness of treatment.
利用改良暗场成像扫描激光检眼镜定量分析并发性白内障黄斑水肿（CME）。
我们研究了 37 只患有不同疾病的 CME 眼，在治疗前后对其进行了评估。通过改良暗场成像和荧光素血管造影来测量 CME 面积。使用 Humphrey 自动视野计测量最佳矫正视力、平均偏差和黄斑敏感性，通过光学相干断层扫描测量中心凹厚度和黄斑体积。
荧光素血管造影能清晰地勾画 50%的 CME 区，改良暗场成像则能清晰地勾画 100%的 CME 区（P < 0.0001）。改良暗场成像计算的 CME 区与荧光素血管造影计算的 CME 区显著相关（P = 0.0001）。治疗前，改良暗场成像计算的 CME 区仅与黄斑体积显著相关（P = 0.0230）。治疗 3 个月后，CME 区的减少与最佳矫正视力、平均偏差、黄斑敏感性、中心凹厚度和黄斑体积的改善显著相关（P < 0.05）。
本研究结果表明，改良暗场成像扫描激光检眼镜可以测量 CME 面积，有助于对 CME 进行定量分析。该方法还可用于评估治疗效果。
