Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Retina. 2012 Oct;32(9):1973-80. doi: 10.1097/IAE.0b013e318251a38b.
To evaluate the relationship between the abnormalities of retinal structures showed on spectral-domain optical coherence tomography and the changes in the macular sensitivity measured by microperimetry in eyes with idiopathic macular telangiectasia type 1.
Eleven eyes of 11 patients with macular telangiectasia type 1 were reviewed. Morphologic changes in the retina and retinal sensitivity of eyes with macular telangiectasia type 1 were studied using spectral-domain optical coherence tomography and microperimetry.
Spectral-domain optical coherence tomographic images revealed disruptions in the photoreceptor inner segment-outer segment (IS/OS) junction in all the eyes and intraretinal cystoid spaces in 10 eyes. In the points that had intraretinal cystoid spaces, the mean retinal sensitivity was 6.8 ± 5.5 dB where the IS/OS was disrupted and 13.4 ± 4.0 dB where the IS/OS was intact (P < 0.001). In the points that had intact IS/OS and no cystoid spaces, the mean retinal sensitivity was 15.3 ± 4.3 dB, which was better than that of points that had intact IS/OS with cystoid spaces (P < 0.001).
Retinal sensitivity is influenced not only by intraretinal cystoid spaces but also by IS/OS disruptions, and the IS/OS alterations reduce the visual function more severely.
评估特发性黄斑毛细血管扩张症 1 型患者眼底结构的异常与微视野计测量的黄斑敏感性变化之间的关系。
回顾性分析 11 例（11 只眼）特发性黄斑毛细血管扩张症 1 型患者。采用频域光学相干断层扫描和微视野计研究特发性黄斑毛细血管扩张症 1 型患者的视网膜形态变化和黄斑敏感性。
所有眼的光感受器内节-外节（IS/OS）连接中断，10 眼出现视网膜内囊样间隙。在存在视网膜内囊样间隙的部位，IS/OS 中断时视网膜平均敏感度为 6.8±5.5dB，IS/OS 完整时为 13.4±4.0dB（P<0.001）。在 IS/OS 完整且无囊样间隙的部位，视网膜平均敏感度为 15.3±4.3dB，优于 IS/OS 完整且存在囊样间隙的部位（P<0.001）。
视网膜敏感性不仅受视网膜内囊样间隙的影响，还受 IS/OS 中断的影响，IS/OS 改变更严重地降低了视力功能。
