School of Chemistry and Biochemistry, Georgia Institute of Technology, 910 Atlantic Drive, Atlanta, Georgia 30332, USA.
J Am Chem Soc. 2012 Apr 25;134(16):6920-3. doi: 10.1021/ja301167y. Epub 2012 Apr 17.
Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared.
阳离子单层保护金纳米粒子 (AuNPs) 的尺寸为 6 或 2nm，与大肠杆菌 (革兰氏阴性) 和枯草芽孢杆菌 (革兰氏阳性) 的细胞膜相互作用，导致 AuNP 表面聚集模式的明显差异或裂解，具体取决于 AuNP 的尺寸。通过透射电子显微镜和紫外-可见光谱研究了聚集现象。对细菌进行蛋白水解处理后，明显的聚集模式消失。
