Samuel Susan M, Hemmelgarn Brenda, Nettel-Aguirre Alberto, Foster Bethany, Soo Andrea, Alexander R Todd, Tonelli Marcello
Alberta Children's Hospital, Calgary, AB, Canada.
Pediatr Transplant. 2012 Nov;16(7):735-41. doi: 10.1111/j.1399-3046.2012.01694.x. Epub 2012 Apr 10.
Many children with ESRD reside far from a kidney transplant center. It is unknown whether this geographical barrier affects likelihood of transplantation. We used data from a national ESRD database. Patients ≤ 18 yr old who started renal replacement in nine Canadian provinces during 1992-2007 were followed until death or last contact. Primary outcome was kidney transplantation (living or deceased donor). Distance between nearest pediatric transplant center and each patient's residence was categorized as: <50, 50 to <150, 150 to <300, and ≥ 300 km. Using survival analysis, we compared likelihood of transplantation between whites and non-whites living in various distance categories. Among 728 patients, 52.2% were males and 62.5% were whites. Compared to white children living < 50 km from a transplant center, white (HR, 0.73; 95% CI, 0.56-0.95) and non-white (HR, 0.66; 95% CI, 0.48-0.92) children living ≥ 300 km away were less likely to receive a transplant. Non-white children living < 50 km away (HR, 0.59; 95% CI 0, 45-0.78) were also less likely to receive a transplant compared to otherwise similar whites living < 50 km away. Although equitable access to transplantation by residence location is observed among remote-dwelling adults with ESRD, white and non-white children with ESRD living ≥ 300 km from a transplant center were less likely to receive transplants.
许多终末期肾病(ESRD)患儿居住在远离肾脏移植中心的地方。尚不清楚这种地理障碍是否会影响移植的可能性。我们使用了一个全国性ESRD数据库的数据。对1992年至2007年期间在加拿大九个省份开始肾脏替代治疗的18岁及以下患者进行随访,直至死亡或最后一次联系。主要结局是肾脏移植(活体或尸体供体)。最近的儿科移植中心与每位患者住所之间的距离分为:<50公里、50至<150公里、150至<300公里和≥300公里。我们使用生存分析比较了居住在不同距离类别的白人和非白人之间的移植可能性。在728名患者中,52.2%为男性,62.5%为白人。与居住在距离移植中心<50公里的白人儿童相比,居住在≥300公里外的白人(风险比[HR],0.73;95%置信区间[CI],0.56 - 0.95)和非白人(HR,0.66;95%CI,0.48 - 0.92)儿童接受移植的可能性较小。与居住在<50公里外的其他情况相似的白人儿童相比,居住在<50公里外的非白人儿童(HR,0.59;95%CI,0.45 - 0.78)接受移植的可能性也较小。虽然在居住在偏远地区的成年ESRD患者中观察到了按居住地点公平获得移植的情况,但居住在距离移植中心≥300公里的ESRD白人儿童和非白人儿童接受移植的可能性较小。