Department of Infectious Disease, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Chin Med J (Engl). 2012 Feb;125(4):710-2.
The infection of Kaposi's sarcoma-associated herpes virus (KSHV) is most likely the cause of clinical Kaposi's sarcoma, primary effusion lymphoma, and multi-center Castleman's disease. KSHV infection has very limited epidemiological survey data in China, and its definite mode of transmission remains controversial. This study aimed to determine the infection status and the main transmission route of KSHV in Chinese population.
An enzyme-linked immunosorbent assay (ELISA) utilizing KSHV ORF65 recombinant protein was employed to analyze the antibody response to KSHV ORF65 in sera from 122 healthy physical examination people, 107 intravenous drug users, 135 non-intravenous drug users, 211 hepatitis B (HBV) patients infected via blood transmission, 107 kidney transplant recipients, and 72 female sex workers in Zhejiang Province in Southeast China.
KSHV infection occurred relatively common (13.1%) in healthy population in Zhejiang, China. Infection rate was 16.7% in female sex workers, but significantly elevated in intravenous drug addicts (58.9%), blood-transmitted HBV patients (28.0%) and kidney transplant patients (41.1%).
Blood borne transmission of KSHV is probably the main route of infection in Zhejiang Province.
卡波氏肉瘤相关疱疹病毒（KSHV）的感染很可能是导致临床卡波氏肉瘤、原发性渗出性淋巴瘤和多中心卡斯特曼病的原因。在中国，关于 KSHV 的感染情况仅有非常有限的流行病学调查数据，其明确的传播方式仍存在争议。本研究旨在确定 KSHV 在中国人群中的感染状况和主要传播途径。
采用酶联免疫吸附试验（ELISA），利用 KSHV ORF65 重组蛋白分析了来自浙江省 122 名健康体检者、107 名静脉吸毒者、135 名非静脉吸毒者、211 名经血液传播感染乙型肝炎病毒（HBV）患者、107 名肾移植受者和 72 名性工作者血清中针对 KSHV ORF65 的抗体反应。
在中国浙江的健康人群中，KSHV 感染较为常见（13.1%）。性工作者的感染率为 16.7%，但静脉吸毒者（58.9%）、经血液传播感染 HBV 患者（28.0%）和肾移植患者（41.1%）的感染率显著升高。
血液传播可能是浙江省 KSHV 的主要感染途径。
