Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan.
Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3054-8. doi: 10.1167/iovs.11-9153.
Toevaluate the effect of removing epiretinal membranes (ERMs) on visual function and vision-related quality of life (VR-QOL) for 12 months postoperatively.
Idiopathic ERMs were removed during vitrectomy in 26 eyes. The VR-QOL was evaluated using a self-administered 25-item National Eye Institute Visual Function Questionnaire before (baseline) and 3 and 12 months postoperatively. During the same periods, the best-corrected visual acuity (BCVA), central macular thickness (CMT), and metamorphopsia score were recorded.
At baseline and months 3 and 12, the logMAR BCVAs (mean ± SEM) were 0.41 ± 0.05, 0.17 ± 0.04 (P = 0.0001 versus baseline), and 0.10 ± 0.03 (P < 0.0001 versus baseline, P = 0.0016 versus month 3), respectively; the CMTs (μm) were 402 ± 18, 312 ± 9 (P < 0.0001 versus baseline), and 300 ± 7 (P < 0.0001 versus baseline, P = 0.0544 versus month 3); and the metamorphopsia scores were 202 ± 29, 137 ± 27 (P = 0.0186 versus baseline), and 108 ± 26 (P = 0.0005 versus baseline, P = 0.0218 versus month 3). In 23 (88%) of 26 eyes, the BCVA improved more than 0.1 logMAR unit at month 12. The improved BCVA was correlated with improvements in two subscales (r = -0.405 to -0.574, P = 0.0041-0.0427) at month 3; the improved metamorphopsia score was correlated with the improved composite score (r = -0.552, P = 0.0058) and three subscales (r = -0.458 to -0.507, P = 0.0113-0.0219) at month 12.
Removing ERMs improved visual function, anatomy, and the VR-QOL. Three months postoperatively, the improved BCVA was the most important factor related to the improved VR-QOL, although the simultaneous cataract surgery might have had a confounding effect. The improved metamorphopsia was the important factor associated with improved VR-QOL 12 months postoperatively.(www.umin.ac.jp/ctr number, UMIN000000617).
评估玻璃体切除术后 12 个月内去除视网膜前膜（ERM）对视觉功能和视觉相关生活质量（VR-QOL）的影响。
26 只眼因特发性 ERM 接受玻璃体切除术。使用自我管理的 25 项国立眼科研究所视觉功能问卷在术前（基线）和术后 3 个月和 12 个月评估 VR-QOL。在相同的时间段内，记录最佳矫正视力（BCVA）、中央黄斑厚度（CMT）和变形分数。
基线和 3 个月和 12 个月时，logMAR BCVA（均值±SEM）分别为 0.41±0.05、0.17±0.04（P=0.0001 与基线相比）和 0.10±0.03（P<0.0001 与基线相比，P=0.0016 与 3 个月相比）；CMT（μm）分别为 402±18、312±9（P<0.0001 与基线相比）和 300±7（P<0.0001 与基线相比，P=0.0544 与 3 个月相比）；变形分数分别为 202±29、137±27（P=0.0186 与基线相比）和 108±26（P=0.0005 与基线相比，P=0.0218 与 3 个月相比）。在 26 只眼中的 23 只（88%），在 12 个月时 BCVA 提高了 0.1 logMAR 单位以上。改善的 BCVA与第 3 个月时两个子量表的改善相关（r=-0.405 至-0.574，P=0.0041-0.0427）；改善的变形分数与改善的综合评分（r=-0.552，P=0.0058）和三个子量表（r=-0.458 至-0.507，P=0.0113-0.0219）相关在第 12 个月。
去除 ERM 改善了视力、解剖结构和 VR-QOL。术后 3 个月，改善的 BCVA 是与改善 VR-QOL 最相关的最重要因素，尽管同期白内障手术可能具有混杂效应。术后 12 个月时，改善的变形分数是与改善 VR-QOL 相关的重要因素。（www.umin.ac.jp/ctr 编号，UMIN000000617）。
