槲皮素对异丙肾上腺素处理大鼠的抗氧化和免疫活性的评价。
Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats.
机构信息
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China.
出版信息
Molecules. 2012 Apr 10;17(4):4281-91. doi: 10.3390/molecules17044281.
Abstract
The present study was designed to evaluate the effect of quercetin on myocardial oxidative stress and immunity function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Wistar rats were subcutaneously injected with isoproterenol (70 mg/kg). Blood immunity index, cardiac marker enzymes and antioxidative parameters in hearts were measured. It was found that the levels of blood AST, creatine kinase, NO, NOS, IL-10, IL-1, IL-8 and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in myocardial antioxidant enzymes activities. Administration of quercetin significantly ameliorated myocardial oxidative injury and immunity function impairment induced by isoproterenol. The results indicated that quercetin possesses activity against isoproterenol-induced myocardial oxidative injury and immunity function impairment, and that the mechanism of pharmacological action was related at least in part to the antioxidant activity of quercetin.
摘要
本研究旨在评价槲皮素对异丙肾上腺素诱导大鼠心肌氧化应激和免疫功能损伤的影响。为了诱导心肌缺血，Wistar 大鼠皮下注射异丙肾上腺素（70mg/kg）。测量心脏血液免疫指标、心脏标志物酶和抗氧化参数。结果发现，异丙肾上腺素处理的大鼠血液 AST、肌酸激酶、NO、NOS、IL-10、IL-1、IL-8 和乳酸脱氢酶水平显著升高。给予异丙肾上腺素的大鼠心肌抗氧化酶活性下降。槲皮素的给药显著改善了异丙肾上腺素诱导的心肌氧化损伤和免疫功能障碍。结果表明，槲皮素有对抗异丙肾上腺素诱导的心肌氧化损伤和免疫功能障碍的作用，其药理作用机制至少部分与槲皮素的抗氧化活性有关。
相似文献
1
Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats.槲皮素对异丙肾上腺素处理大鼠的抗氧化和免疫活性的评价。
Molecules. 2012 Apr 10;17(4):4281-91. doi: 10.3390/molecules17044281.
2
Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats.预先用槲皮素和α-生育酚联合处理可改善心肌梗死大鼠的三磷酸腺苷酶和溶酶体酶。
Life Sci. 2010 Jan 30;86(5-6):178-84. doi: 10.1016/j.lfs.2009.11.021. Epub 2009 Dec 1.
3
Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats.山奈酚对异丙肾上腺素诱导的大鼠心脏毒性实验模型中的氧化应激和细胞凋亡损伤具有保护作用。
Phytomedicine. 2016 Nov 15;23(12):1401-1408. doi: 10.1016/j.phymed.2016.07.015. Epub 2016 Aug 4.
4
The cardioprotective effects of a combination of quercetin and α-tocopherol on isoproterenol-induced myocardial infarcted rats.槲皮素和 α-生育酚联合对异丙肾上腺素诱导心肌梗死大鼠的心脏保护作用。
J Biochem Mol Toxicol. 2011 Jan-Feb;25(1):28-40. doi: 10.1002/jbt.20357.
5
Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats.麦冬多糖对异丙肾上腺素致大鼠心肌缺血的保护作用。
Int J Biol Macromol. 2020 Mar 15;147:233-240. doi: 10.1016/j.ijbiomac.2020.01.068. Epub 2020 Jan 8.
6
Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats.人参皂苷 Rb3 对异丙肾上腺素诱导的大鼠心肌损伤及心功能障碍的影响。
Eur J Pharmacol. 2010 Jun 25;636(1-3):121-5. doi: 10.1016/j.ejphar.2010.03.035. Epub 2010 Apr 2.
7
Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats.人参皂苷 Rh1 对异丙肾上腺素诱导的大鼠心肌损伤及心功能的影响。
Toxicol Mech Methods. 2012 Oct;22(8):584-91. doi: 10.3109/15376516.2012.702798. Epub 2012 Jul 18.
8
Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system.姜黄素保护大鼠心肌对抗异丙肾上腺素诱导的缺血性损伤：通过增加热休克蛋白 27 的表达以及增强抗氧化防御系统来减轻心室功能障碍。
J Cardiovasc Pharmacol. 2010 Apr;55(4):377-84. doi: 10.1097/FJC.0b013e3181d3da01.
9
Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats.肉桂酸和肉桂醛对异丙肾上腺素诱导的大鼠急性心肌缺血的保护作用。
J Ethnopharmacol. 2013 Oct 28;150(1):125-30. doi: 10.1016/j.jep.2013.08.019. Epub 2013 Aug 31.
10
Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats.槲皮素增强了氯沙坦对大鼠慢性多柔比星心脏毒性的保护作用。
Environ Toxicol Pharmacol. 2013 Sep;36(2):443-450. doi: 10.1016/j.etap.2013.05.006. Epub 2013 May 27.
引用本文的文献
1
Implications of Quercetin in Mitigating Myocardial Ischemia-Reperfusion Injury: A Review Study.槲皮素在减轻心肌缺血再灌注损伤中的作用：一项综述研究
Adv Biomed Res. 2025 Feb 28;14:17. doi: 10.4103/abr.abr_166_24. eCollection 2025.
2
Immunological effects of ractopamine in rabbits receiving the viral inactivated rabbit hemorrhagic disease vaccine.盐酸克伦特罗对兔出血症病毒灭活疫苗免疫兔的免疫效果。
Open Vet J. 2024 Jan;14(1):136-143. doi: 10.5455/OVJ.2024.v14.i1.12. Epub 2024 Jan 31.
3
Reduction of Doxorubicin-Induced Cardiotoxicity by Co-Administration of Smart Liposomal Doxorubicin and Free Quercetin: In Vitro and In Vivo Studies.联合使用智能脂质体阿霉素和游离槲皮素降低阿霉素诱导的心脏毒性：体外和体内研究
Pharmaceutics. 2023 Jul 11;15(7):1920. doi: 10.3390/pharmaceutics15071920.
4
(Combretaceae): Pharmacological Effects, LC-ESI-MS/MS Profiling and In Silico Attributes.（使君子科）：药理作用、液相色谱-电喷雾串联质谱分析及计算机模拟特性
Metabolites. 2023 Jun 27;13(7):794. doi: 10.3390/metabo13070794.
5
Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health.槲皮素糖苷作为对人类健康具有抗动脉粥样硬化作用的食物衍生因子的潜在作用。
Antioxidants (Basel). 2023 Jan 23;12(2):258. doi: 10.3390/antiox12020258.
6
Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion.番茄红素减轻缺血再灌注损伤的作用。
Oxid Med Cell Longev. 2022 Oct 7;2022:9309327. doi: 10.1155/2022/9309327. eCollection 2022.
7
Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin.抗氧化剂对再灌注损伤的心脏保护作用：白藜芦醇和槲皮素的潜在治疗作用。
Molecules. 2022 Apr 15;27(8):2564. doi: 10.3390/molecules27082564.
8
Effect of Consumption During Pregnancy on Maternal Mice and Their Offspring.孕期消费对母鼠及其后代的影响。
J Med Food. 2022 Feb;25(2):183-191. doi: 10.1089/jmf.2021.0078. Epub 2021 Oct 29.
9
Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis.氧化应激传感器蛋白匹啉在上皮癌发生中的作用
Biology (Basel). 2021 Feb 4;10(2):116. doi: 10.3390/biology10020116.
10
Neuroprotective potential of hydroethanolic hull extract of L. on isoprenaline induced oxidative damage in brain of Wistar rats.荔枝核水乙醇提取物对异丙肾上腺素诱导的Wistar大鼠脑氧化损伤的神经保护潜力。
Toxicol Rep. 2021 Jan 18;8:223-229. doi: 10.1016/j.toxrep.2021.01.006. eCollection 2021.
本文引用的文献
1
Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells.槲皮素对过氧化氢诱导的人神经母细胞瘤 SH-SY5Y 细胞凋亡的保护作用。
Neurosci Lett. 2011 Oct 31;504(3):223-7. doi: 10.1016/j.neulet.2011.09.028. Epub 2011 Sep 21.
2
Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.槲皮素在人离体和体内模型中的抗炎、抗增殖和抗动脉粥样硬化作用。
Atherosclerosis. 2011 Sep;218(1):44-52. doi: 10.1016/j.atherosclerosis.2011.04.023. Epub 2011 May 5.
3
Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats.槲皮素抑制 Walker 256 荷瘤大鼠肿瘤生长、提高存活率并预防恶病质。
Biochem Biophys Res Commun. 2011 Mar 25;406(4):638-42. doi: 10.1016/j.bbrc.2011.02.111. Epub 2011 Mar 6.
4
[Comparative study on the antioxidant capacity of quercetin in vivo and in vitro].槲皮素体内外抗氧化能力的比较研究
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 Nov;18(4):382-6.
5
Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.丹参酸 B 和丹皮酚对垂体后叶素致心肌缺血兔血脂代谢及血液流变学的影响。
Int J Mol Sci. 2010 Sep 28;11(10):3696-704. doi: 10.3390/ijms11103696.
6
Extraction, chemical analysis of Angelica sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats.当归多糖的提取、化学分析及对缺血再灌注大鼠的抗氧化活性。
Int J Biol Macromol. 2010 Nov 1;47(4):546-50. doi: 10.1016/j.ijbiomac.2010.07.012. Epub 2010 Aug 5.
7
Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase.蝶呤中心自由基作为一氧化氮合酶第二步的机理探针。
J Am Chem Soc. 2010 Apr 14;132(14):5105-13. doi: 10.1021/ja909378n.
8
Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice.槲皮素微乳液对小鼠气道变应性炎症模型的抗炎作用。
Pharmacol Res. 2010 Apr;61(4):288-97. doi: 10.1016/j.phrs.2009.10.005. Epub 2009 Nov 3.
9
Health effects of quercetin: from antioxidant to nutraceutical.槲皮素对健康的影响：从抗氧化剂到营养保健品。
Eur J Pharmacol. 2008 May 13;585(2-3):325-37. doi: 10.1016/j.ejphar.2008.03.008. Epub 2008 Mar 18.
10
Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat.氟伐他汀对异丙肾上腺素诱导的大鼠心肌梗死的心脏保护作用。
Eur J Pharmacol. 2008 May 31;586(1-3):244-50. doi: 10.1016/j.ejphar.2008.02.057. Epub 2008 Mar 4.
Zotero 插件