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氧化应激传感器蛋白匹啉在上皮癌发生中的作用

Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis.

作者信息

Perez-Dominguez Francisco, Carrillo-Beltrán Diego, Blanco Rancés, Muñoz Juan P, León-Cruz Grettell, Corvalan Alejandro H, Urzúa Ulises, Calaf Gloria M, Aguayo Francisco

机构信息

Laboratorio Oncovirología, Programa de Virología, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago 8380000, Chile.

Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.

出版信息

Biology (Basel). 2021 Feb 4;10(2):116. doi: 10.3390/biology10020116.

DOI:10.3390/biology10020116
PMID:33557375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7915911/
Abstract

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.

摘要

吡啉是一种氧化应激（OS）传感器，属于功能多样的铜离子超家族蛋白。吡啉被认为是一种槲皮素酶，也是活化B细胞核因子κB轻链增强子（NF-κB）途径的转录激活剂。其在癌症发展中的生物学作用仍是一个新的研究领域。本综述展示了关于吡啉在上皮性癌中的作用、相关信号通路以及作为潜在治疗靶点的越来越多的证据。最后，我们提出了一个模型，其中吡啉在参与氧化应激和癌症发展的物理、化学或生物因素作用下被上调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/db568e310588/biology-10-00116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/4a262d215e5d/biology-10-00116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/04bbb40ec2a9/biology-10-00116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/1ab4b0e78169/biology-10-00116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/66c18e9add37/biology-10-00116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/db568e310588/biology-10-00116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/4a262d215e5d/biology-10-00116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/04bbb40ec2a9/biology-10-00116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/1ab4b0e78169/biology-10-00116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/66c18e9add37/biology-10-00116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/7915911/db568e310588/biology-10-00116-g005.jpg

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